TY  - THES 
TI  - Estudio del efecto de los sistemas poliméricos PAM-18 K2 y PAM-18 Na2 sobre los perfiles de disolución de comprimidos de ampicilina
PB  - Universidad Icesi
PY  - 2013
UR  - http://hdl.handle.net/10906/76833
AB  - The present grade project is part of an investigation work with a bigger scope, which is focused in the research of the characterization of physicochemical properties in aqueous solutions of polymer materials with amphiphilic characteristics, with the purpose to evaluate their potential as novel pharmaceutical matrices capable to decrease the biodegradability of betalactamic drugs. Specifically, in this grade project, the variation in dissolution profiles of commercial tablets of the betalactamic drug ampicillin in its trihydrate form was evaluated, in presence of the polymer materials PAM-18Na2, PAM-18 K2 and Eudragit E-100 Chloride in media with physiologic conditions of pH and ionic strength modified by action from the polymeric systems in dispersion, with pH values of 1,2 and 7,4 and ionic strength of 0,15 M in a temperature of 37°C.
KW  - Ampicilina trihidratada
KW  - Sal sódica del poli(ácido maléico-alt-octadeceno)
KW  - Sal dipotásica del poli(ácido maléico-alt-octadeceno)
KW  - Eudragit® E-100
KW  - Perfil de disolución
KW  - Area bajo la curva
KW  - Fisicoquímica farmacéutica
KW  - Control de calidad
KW  - Biofarmacia
KW  - Producción intelectual registrada - Universidad Icesi
KW  - Conservación de la biodiversidad
KW  - Biodiversity conservation
ER  -