TY  - THES 
TI  - Evaluación del material polimérico clorhidrato de EUDRAGIT E-100 como potencial excipiente de liberación modificada de fármacos en matrices sólidas
PB  - Universidad Icesi
PY  - 2014
UR  - http://hdl.handle.net/10906/76908
AB  - The effect of the polymer system modified Clorhidrato Eudragit E-100, as modified 
release excipient potential on the dissolution profile of the drug model, 5H-dibenzo 
[b, f] azepine-5-carboxamide in aqueous media was determined and two systems 
buffer pH 1.2 and 7.4 with 0.15M ionic strength at 37 ° C temperature
In this study were obtained validation parameters of the method for the 
quantification the drug such as: selectivity, repeatability, reproducibility and 
linearity.
Also were performed previous studies for determining specific parameters for 
obtaining the tablets of the study. Among these are hardness, moisture adsorption 
capacity, diameter, thickness and disintegration time. Once these characteristics 
are determined, were evaluated dissolution profiles for the tablets of the study and 
reference, these tablets were composed of Clorhidrato de Eudragit E100 and 
microcrystalline cellulose pH 102, respectively, together with the model drug in 
proportions 1:1 polymer: drug. The data obtained were analyzed by a statistical 
analysis (ANOVA), which established one significant effect between the dissolution 
medium (buffer pH 1.2, aqueous medium and buffer pH 7.4) and polymeric system, 
on the dissolution percentage of the drug. This study concluded that the polymer 
system of study, no delay of release the drug, because is observed the behavior of 
an immediate release dosage form.

KW  - Materiales poliméricos
KW  - Eudragit® E-100
KW  - Sistemas poliméricos
KW  - Perfil de disolución
KW  - Métodos de investigación en bioquímica
KW  - Biochemistry research
KW  - Producción intelectual registrada - Universidad Icesi
KW  - Dissolution Profile
KW  - Modified release system
ER  -