Authors Title Year Link Abstract Keywords Publisher Pubplace Language Document Type "Calcium, channels, intracellular signaling and autoimmunity" 2014 "http://hdl.handle.net/10906/78344" "Calcium (Ca2+) is an important cation able to function as a second messenger in different cells of theimmune system, particularly in B and T lymphocytes, macrophages, and mastocytes, among others.Recent discoveries related to the entry of Ca2+ through the store-operated calcium entry (SOCE) haveopened a new investigation area about the cell destiny regulated by Ca2+ especially in B and T lymphocytes.SOCE acts through calcium-release-activated calcium (CRAC) channels. The function of CRACdepends upon two recently discovered regulators: the Ca2+ sensor in the endoplasmic reticulum orstromal interaction molecule (STIM-1) and one subunit of CRAC channels called Orai1.This review focuses on the role of Ca2+ signals in B and T lymphocytes functions, the signaling pathwaysleading to Ca2+ influx, and the relationship between Ca2+ signals and autoimmune diseases." "Calcio ,Enfermedades autoinmunes ,Ciencias socio biomédicas ,Medical sciences ,Linfocitos T" "spa" "info:eu-repo/semantics/article"