DSpace Comunidad :http://repository.icesi.edu.co/biblioteca_digital/handle/10906/781912024-03-28T23:21:48Z2024-03-28T23:21:48ZVascular disruption birth defects are not associated to chromosomal alterationsPachajoa Londoño, Harry MauricioMéndez, FabiánAriza, YosethIsaza, Carolinahttp://repository.icesi.edu.co/biblioteca_digital/handle/10906/822952017-11-23T22:10:31Z2015-11-01T00:00:00ZTítulo : Vascular disruption birth defects are not associated to chromosomal alterations
Autor : Pachajoa Londoño, Harry Mauricio; Méndez, Fabián; Ariza, Yoseth; Isaza, Carolina
Colaboradores : Pachajoa Londoño, Harry Mauricio; Méndez, Fabián; Ariza, Yoseth; Isaza, Carolina
Resumen : Antecedentes: 2 a 3% de los recién nacidos tienen un defecto congénito; algunos de los debidos a disrupción vascular no se relacionan con alteraciones cromosómicas detectadas por cariotipo convencional.
Objetivo: determinar, en pacientes con defectos por disrupción vascular de una población colombiana, la frecuencia de alteraciones cromosómicas detectadas por cariotipo bandeo G de alta resolución.
Material y método: estudio transversal efectuado en una muestra de
pacientes identificados por el sistema de vigilancia de defectos congénitos en un hospital de referencia de Cali, Colombia.
Resultados: en un periodo de 36 meses se identificaron 41 casos con defectos por disrupción vascular. Los más frecuentes fueron: reducción transversal, hidranencefalia y gastrosquisis. En la evaluación independiente por dos citogenetistas expertos, en ninguna de las muestras se identificaron alteraciones cromosómicas por medio del cariotipo con bandeo G.
Conclusiones: se recomienda que la asesoría genética a los casos de defectos por disrupción vascular se efectúe teniendo en cuenta los riesgos de recurrencia empíricos reportados para cada de uno los tipos de defectos por disrupción vascular y el uso del cariotipo debe limitarse a los casos con otras malformaciones o sospecha de alteración cromosómica por el fenotipo.
Descripción : It is estimated that 2 to 35 of newborns present a congenital malformation. Some publications suggest that vascular disruption birth defects are not associated with chromosomal alterations detected by conventional karyotype. Objective: to determine the frequency of chromosomal alterations detected by high resolution G banded karyotype in patients with vascular disruption birth defects in a Colombian population (South America). Material and method: transversal study. Population: a sample of patients identified by an epidemiological surveillance system of congenital malformations in a reference hospital in Cali, Colombia. Results: 41 cases of vascular disruption birth defects were identified during a 36 month period; in a descending order those were: transverse reduction defects, hydranencephaly and gastroschisis. Two expert cytogenetists performed independent evaluation of the genetic material of the patients, and no chromosomal alterations detectable by G banded karyotype were identified. Conclusions: It is recommended that genetic counseling in cases of defects by vascular disruption is carried out taking into account the empirical recurrence risks reported for each one the types of defects by vascular disruption and the use of karyotype should be limited to cases with other malformations or chromosomal abnormality suspected by phenotype.2015-11-01T00:00:00ZRegistro de trauma de la Sociedad Panamericana de Trauma: Un año de experiencia en dos hospitales en el suroccidente colombianoPuyana, Juan CarlosGutiérrez-Martínez, Maria IsabelHerrera, Mario AlainPino, Luis FernandoGonzález, AdolfoBadiel, MarisolRojas-Mirquez, Johanna CarolinaOrdóñez, Carlos AlbertoIvatury, Rao R.Abutanos, MichaelUribe-Gómez, AmadeusArana, Fernando MiñánBonilla-Escobar, Francisco JavierMorales, Mónicahttp://repository.icesi.edu.co/biblioteca_digital/handle/10906/822972017-11-24T12:32:00Z2016-01-01T00:00:00ZTítulo : Registro de trauma de la Sociedad Panamericana de Trauma: Un año de experiencia en dos hospitales en el suroccidente colombiano
Autor : Puyana, Juan Carlos; Gutiérrez-Martínez, Maria Isabel; Herrera, Mario Alain; Pino, Luis Fernando; González, Adolfo; Badiel, Marisol; Rojas-Mirquez, Johanna Carolina; Ordóñez, Carlos Alberto; Ivatury, Rao R.; Abutanos, Michael; Uribe-Gómez, Amadeus; Arana, Fernando Miñán; Bonilla-Escobar, Francisco Javier; Morales, Mónica
Colaboradores : Puyana, Juan Carlos; Gutiérrez-Martínez, Maria Isabel; Herrera, Mario Alain; Pino, Luis Fernando; González, Adolfo; Badiel, Marisol; Rojas-Mirquez, Johanna Carolina; Ordóñez, Carlos Alberto; Ivatury, Rao R.; Abutanos, Michael; Uribe-Gómez, Amadeus; Arana, Fernando Miñán; Bonilla-Escobar, Francisco Javier; Morales, Mónica
Resumen : Background: Emergency care information systems in trauma are essential to improve the decision making and identify potential areas of intervention. Objective: To describe the first year of experience of trauma registry in two reference trauma centers of the southwestern Colombia. Methods: A study conducted in two reference trauma centers of Cali city. There were included those patients with any injury from external causes or trauma occurred between January 1st and December 31st of 2012. Information related with demographics, injury mechanism, severity injury (ISS) and mortality were collected. We presented a descriptive analysis. Results: There were registered 17,431 patients whereof 67.8% were male with a mean of 30 (±20) years old. Workplace injuries were the 28.2% cause of emergency consultation, and falls were the most prevalent trauma mechanism. Majority of patients with a ISS ≥15 were in a range age of 18-35 years (6.4%). The 28% of patients with gunshot wounds had a ISS ≥15. An overall of 2.5% of included patients died and those who had a ISS ≥15 and gunshot wounds showed a mortality of 54%. Conclusion: Upon the implementation of the trauma registry in two main hospitals of Cali city, we identify that falls and workplace injuries were the leading cause of admission to the emergency room. Severely compromised patients are in the range age of 18-35 years old. Mortality was higher for those patients who suffered gunshot wounds.
Descripción : Introducción: Los sistemas de información en trauma son requeridos para mejorar la toma de decisiones e identificar potenciales áreas de intervención.
Objetivo: Describir el primer año de experiencia del registro de trauma en dos centros de referencia de trauma del suroccidente Colombiano.
Métodos: Estudio realizado en dos centros de referencia de Cali. Se incluyeron pacientes con trauma o lesiones externas entre el 1-Ene y el 31-Dic-2012. Se recolectó información demográfica, relacionada con mecanismos de trauma, severidad (ISS) y mortalidad. Se presenta un análisis descriptivo.
Resultados: Se registraron 17,431 pacientes. El 67.8% de los pacientes eran de género masculino con edad promedio de 30 (±20) años. Las lesiones laborales fueron causa de consulta a urgencias en un 28.2%, y las caídas el mecanismo de trauma más frecuente (37.3%). Los pacientes con ISS ≥15 en su mayoría se encontraban en el rango de edad de 18-35 años (6.4%). El 28% de los pacientes que sufrieron lesión por arma de fuego presentaron un ISS ≥15. El 2.5% de los pacientes murieron y aquellos pacientes con ISS ≥15 y lesión por arma de fuego presentaron mortalidad del 54%.
Conclusión: Una vez se logró implementar el registro de trauma en dos instituciones en Cali, se identificó que la principal causa de ingreso fue secundaria a caídas y las lesiones laborales. Los pacientes más severamente comprometidos están en el rango de población entre 18 a 35 años. La mayor mortalidad se presentó secundario a lesiones de causa externa por arma de fuego.2016-01-01T00:00:00ZSyndromic microphthalmia-3 caused by a mutation on gene SOX2 in a Colombian male patientPachajoa Londoño, Harry MauricioRamirez-Botero, Andrés Felipehttp://repository.icesi.edu.co/biblioteca_digital/handle/10906/822962018-10-19T22:31:15Z2016-11-01T00:00:00ZTítulo : Syndromic microphthalmia-3 caused by a mutation on gene SOX2 in a Colombian male patient
Autor : Pachajoa Londoño, Harry Mauricio; Ramirez-Botero, Andrés Felipe
Colaboradores : Pachajoa Londoño, Harry Mauricio; Ramirez-Botero, Andrés Felipe
Resumen : Syndromic microphthalmia-3 is a rare congenital syndrome associated with brain anomalies, esophageal atresia and genital anomalies. This is the case of a 4-year-old male with bilateral microphthalmia, short stature, neurodevelopmental delay, genital anomalies, and maternal exposition to glyphosate during pregnancy. Genetic testing detected a previously reported pathogenic heterozygous mutation in the SOX2 gene, confirming a diagnosis of syndromic microphthalmia-3. Whenever a patient presents bilateral microphthalmia, it is necessary to determine whether it is isolated or syndromic; afterwards, genetic testing should be performed in order to offer an effective genetic counseling.2016-11-01T00:00:00ZThe Endothelium in SepsisInce, CanDe Backer, DanielMurray, PatrickHernandez, GlennOspina-Tascón, Gustavo A.Kellum, John A.Gomez, HernandoNguyen, TrungMayeux, Philip R.http://repository.icesi.edu.co/biblioteca_digital/handle/10906/822922018-10-05T18:41:21Z2016-03-01T00:00:00ZTítulo : The Endothelium in Sepsis
Autor : Ince, Can; De Backer, Daniel; Murray, Patrick; Hernandez, Glenn; Ospina-Tascón, Gustavo A.; Kellum, John A.; Gomez, Hernando; Nguyen, Trung; Mayeux, Philip R.
Colaboradores : Ince, Can; De Backer, Daniel; Murray, Patrick; Hernandez, Glenn; Ospina-Tascón, Gustavo A.; Kellum, John A.; Gomez, Hernando; Nguyen, Trung; Mayeux, Philip R.
Resumen : Sepsis affects practically all aspects of endothelial cell (EC) function and is thought to be the key factor in the progression from sepsis to organ failure. Endothelial functions affected by sepsis include vasoregulation, barrier function, inflammation, and hemostasis. These are among other mechanisms often mediated by glycocalyx shedding, such as abnormal nitric oxide metabolism, up-regulation of reactive oxygen species generation due to down-regulation of endothelial-associated antioxidant defenses, transcellular communication, proteases, exposure of adhesion molecules, and activation of tissue factor. This review covers current insight in EC-associated hemostatic responses to sepsis and the EC response to inflammation. The endothelial cell lining is highly heterogeneous between different organ systems and consequently also in its response to sepsis. In this context, we discuss the response of the endothelial cell lining to sepsis in the kidney, liver, and lung. Finally, we discuss evidence as to whether the EC response to sepsis is adaptive or maladaptive. This study is a result of an Acute Dialysis Quality Initiative XIV Sepsis Workgroup meeting held in Bogota, Columbia, between October 12 and 15, 2014.2016-03-01T00:00:00ZUnderstanding the venous–arterial CO2 to arterial–venous O2 content difference ratioOspina-Tascón, Gustavo A.Cecconi, MaurizioHernández, Glennhttp://repository.icesi.edu.co/biblioteca_digital/handle/10906/822942018-10-26T22:29:38Z2016-11-12T00:00:00ZTítulo : Understanding the venous–arterial CO2 to arterial–venous O2 content difference ratio
Autor : Ospina-Tascón, Gustavo A.; Cecconi, Maurizio; Hernández, Glenn
Colaboradores : Ospina-Tascón, Gustavo A.; Cecconi, Maurizio; Hernández, Glenn
Resumen : Introduction Early identification of tissue hypoperfusion is a cornerstone of shock management [1]. Normal macrohemodynamic and oxygen-derived parameters do not, however, rule out the presence of tissue hypoxia [2]. In this setting, carbon dioxide (CO2)-derived variables may provide information on macroand microvascular blood flow [3] and also on the presence of anaerobic metabolism [4, 5]. Importantly, variations in CO2 occur more rapidly than changes in lactate kinetics, making the former an attractive biomarker for monitoring, especially during the early stages of resuscitation [6, 7].2016-11-12T00:00:00ZSuccessful Treatment with Bone Marrow Transplantation in a Children with Familial Hemophagocytic Lymphohistiocytosis Type 3 (FHL3) with Mutation Homozygous c.9049G > A in Gen UNc13DOlaya Hernandez, ManuelaSilva, NoraSerna, LorenaLotero, VivianaPachajoa Londoño, Harry MauricioPerez, PaolaMedina, DiegoPatino, Jaimehttp://repository.icesi.edu.co/biblioteca_digital/handle/10906/822932020-06-03T19:12:37Z2015-11-01T00:00:00ZTítulo : Successful Treatment with Bone Marrow Transplantation in a Children with Familial Hemophagocytic Lymphohistiocytosis Type 3 (FHL3) with Mutation Homozygous c.9049G > A in Gen UNc13D
Autor : Olaya Hernandez, Manuela; Silva, Nora; Serna, Lorena; Lotero, Viviana; Pachajoa Londoño, Harry Mauricio; Perez, Paola; Medina, Diego; Patino, Jaime
Colaboradores : Olaya Hernandez, Manuela; Silva, Nora; Serna, Lorena; Lotero, Viviana; Pachajoa Londoño, Harry Mauricio; Perez, Paola; Medina, Diego; Patino, Jaime
Resumen : Conferencia: 4ta Reunión de la Sociedad Latinoamericana de Inmunodeficiencias (LASID) Volumen: 35 sobre Tratamiento exitoso con trasplante de médula ósea en niños con linfohistiocitosis hemofagocítica familiar tipo 3 (FHL3) con mutación homocigota c.9049G> A en gen UNc13D2015-11-01T00:00:00ZTrasplante combinado hígado-riñón en la Fundación Valle del Lili, Cali, Colombia - Experiencia de un centroEcheverri Junca, Gabriel JaimeCaicedo R., Luis ArmandoDurán R, Carlos EduardoBotero O, VerónicaVillegas O, Jorge IvánSerrano A, Oscar JavierSchweineberg L, JohanaPosada Ch, Juan GuillermoMesa R, LilianaSepúlveda C, MauricioGarcía A, Jairo AlbertoJimenez R, Diego FernandoManzi T, ElianaValderrama M, María LucíaVernaza O, Cristinahttp://repository.icesi.edu.co/biblioteca_digital/handle/10906/822912017-11-24T12:31:59Z2016-04-01T00:00:00ZTítulo : Trasplante combinado hígado-riñón en la Fundación Valle del Lili, Cali, Colombia - Experiencia de un centro
Autor : Echeverri Junca, Gabriel Jaime; Caicedo R., Luis Armando; Durán R, Carlos Eduardo; Botero O, Verónica; Villegas O, Jorge Iván; Serrano A, Oscar Javier; Schweineberg L, Johana; Posada Ch, Juan Guillermo; Mesa R, Liliana; Sepúlveda C, Mauricio; García A, Jairo Alberto; Jimenez R, Diego Fernando; Manzi T, Eliana; Valderrama M, María Lucía; Vernaza O, Cristina
Colaboradores : Echeverri Junca, Gabriel Jaime; Caicedo R., Luis Armando; Durán R, Carlos Eduardo; Botero O, Verónica; Villegas O, Jorge Iván; Serrano A, Oscar Javier; Schweineberg L, Johana; Posada Ch, Juan Guillermo; Mesa R, Liliana; Sepúlveda C, Mauricio; García A, Jairo Alberto; Jimenez R, Diego Fernando; Manzi T, Eliana; Valderrama M, María Lucía; Vernaza O, Cristina
Resumen : Introducción: el trasplante combinado de hígado y riñón (CLK) ha mostrado ser una buena alternativa para pacientes con diagnóstico concomitante de enfermedad renal crónica (ERC) y enfermedad hepática terminal. Algunos estudios han mostrado además un beneficio inmunológico del trasplante combinado, con disminución de la tasa de rechazo del injerto renal.
Descripción : Introduction: Combined liver and kidney transplantation (CLK) has been shown to be a good alternative for patients with concomitant diagnosis of chronic kidney disease (CKD) and end-stage liver disease. Some studies have also shown immunological benefits from combined transplantation with decreased rates of kidney graft rejection. Introducción: el trasplante combinado de hígado y riñón (CLK) ha mostrado ser una buena alternativa para pacientes con diagnóstico concomitante de enfermedad renal crónica (ERC) y enfermedad hepática terminal. Algunos estudios han mostrado además un beneficio inmunológico del trasplante combinado, con disminución de la tasa de rechazo del injerto renal.2016-04-01T00:00:00ZSoluble or soluble/membrane TNF-± inhibitors protect the brain from focal ischemic injury in ratsArango Dávila, César AugustoCardozo, Carlos F.Londoño, Ana C.Cañas, Carlos A.Rengifo, JulianaOrozco, Jorge LuisCañas, FelipeEcheverri, Andrés F.Vera, Alejandrohttp://repository.icesi.edu.co/biblioteca_digital/handle/10906/822902020-05-08T00:41:51Z2015-12-02T00:00:00ZTítulo : Soluble or soluble/membrane TNF-± inhibitors protect the brain from focal ischemic injury in rats
Autor : Arango Dávila, César Augusto; Cardozo, Carlos F.; Londoño, Ana C.; Cañas, Carlos A.; Rengifo, Juliana; Orozco, Jorge Luis; Cañas, Felipe; Echeverri, Andrés F.; Vera, Alejandro
Colaboradores : Arango Dávila, César Augusto; Cardozo, Carlos F.; Londoño, Ana C.; Cañas, Carlos A.; Rengifo, Juliana; Orozco, Jorge Luis; Cañas, Felipe; Echeverri, Andrés F.; Vera, Alejandro
Resumen : Tumor Necrosis Factor-alpha (TNF-α) is an immunomodulatory and proinflammatory cytokine implicated in neuro-inflammation and neuronal damage in response to cerebral ischemia. The present study tested the hypothesis that anti-TNF-α agents may be protective against cerebral infarction. Transient focal ischemia was artificially induced in anesthetized adult male Wistar rats (300–350 g) by middle cerebral artery occlusion (MCAO) with an intraluminal suture. TNF-α function was interfered with either a chimeric monoclonal antibody against TNF-α (infliximab-7 mg/kg) aiming to TNF-α soluble and membrane-attached form; or a chimeric fusion protein of TNF-α receptor-2 with a fragment crystallizable (Fc) region of IgG1 (etanercept-5 mg/kg) aiming for the TNF-α soluble form. Both agents were administered intraperitoneally 0 or 6 h after inducing ischemia. Infarct volume was measured by 2,3,5-triphenyltetrazolium chloride staining. Cerebral infarct volume was significantly reduced in either etanercept or infliximab-treated group compared with non-treated MCAO rats 24 h after reperfusion. These results suggest that anti-TNF-α agents may reduce focal ischemic injury in rats.2015-12-02T00:00:00Z Efficacy of anti-interleukin-6 receptor antibody (tocilizumab) in colombian patients with takayasu’s arteritisIzquierdo, Jorge H.Cañas Dávila, Carlos AlbertoBonilla Abadía, Fabiohttp://repository.icesi.edu.co/biblioteca_digital/handle/10906/822702017-11-16T09:31:42Z2013-06-01T00:00:00ZTítulo : Efficacy of anti-interleukin-6 receptor antibody (tocilizumab) in colombian patients with takayasu’s arteritis
Autor : Izquierdo, Jorge H.; Cañas Dávila, Carlos Alberto; Bonilla Abadía, Fabio
Colaboradores : Izquierdo, Jorge H.; Cañas Dávila, Carlos Alberto; Bonilla Abadía, Fabio
Resumen : Background Takayasu’s arteritis (TA) is a chronic vasculitis that involves aorta and its main branches, where interleukin-6 (IL-6) seems to play a pathogenic role (1,2). The effect in four patients treated with the anti-IL-6 receptor (IL-6R) antibody Tocilizumab was evaluated. Objectives to describe the effect of Tocilizumab in patients of Takayasu’s arteritis. Methods We reviewed the clinical records of 4 patients with TA diagnosed according to current criteria, treated between 2010 and 2011 in a tertiary center in Cali, Colombia. Four patients with a refractory disease to multiple treatments, was began treatment with Tocilizumab at a dose of 8 mg/kg every month in association with metothrexate and/or steroids. Two patients were treated previously with infliximab (IFX) without control of disease. This cases were reported previously (3). Results The cases summaries are as follows: Case 1. A 30 year-old woman with a diagnosis of TA since 2003 presented panaortitis, with involvement of supra-aortic,2013-06-01T00:00:00ZComparative evaluation of adhesion formation of prosthetic meshes after intra-abdominal implantation in wistar ratsValladares Torres, LilianaFranco, M. H.Arboleda, A.Echeverry Junca, Gabriel Jaimehttp://repository.icesi.edu.co/biblioteca_digital/handle/10906/822692018-10-09T16:26:54Z2014-07-10T00:00:00ZTítulo : Comparative evaluation of adhesion formation of prosthetic meshes after intra-abdominal implantation in wistar rats
Autor : Valladares Torres, Liliana; Franco, M. H.; Arboleda, A.; Echeverry Junca, Gabriel Jaime
Colaboradores : Valladares Torres, Liliana; Franco, M. H.; Arboleda, A.; Echeverry Junca, Gabriel Jaime
Resumen : Increasingly biomaterials for the repair of abdominal wall defects are used. The aim of this study was to evaluate adhesion formation of prosthetic meshes after intraabdominal implantation to repair a surgical defect in the anterior abdominal wall. This anatomical defect was repaired by one of the three types of previously sterilized meshes: 1) fibroin 2) fibroin with polyethylene glycol and 3) commercial polypropylene mesh as control. The grip score was significantly higher in the commercial polypropylene mesh. Fibroin is a promising biomaterial for treating defects of the abdominal wall.2014-07-10T00:00:00Z