Please use this identifier to cite or link to this item: http://repository.icesi.edu.co/biblioteca_digital/handle/10906/78472
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dc.creatorCañas Dávila, Carlos Albertospa
dc.creatorAnaya, Juan Manuel-
dc.creatorPrahalad, Sampath-
dc.creatorCherñavsky, Alejandra-
dc.creatorRojas Villarraga, Adrianaspa
dc.creatorBohnsack, Johneng
dc.creatorJonsson, Roland-
dc.creatorBolstad, Anne Isine-
dc.creatorBrun, Johan G.-
dc.creatorCobb, Beth-
dc.creatorMoser, Kathy L.-
dc.creatorJames, Judith A.-
dc.creatorNath, Swapan K.-
dc.date.accessioned2015-10-13T21:05:57Z-
dc.date.available2015-10-13T21:05:57Z-
dc.date.issued2012-02-12-
dc.identifier.ismn0896-8411-
dc.identifier.otherhttp://apps.webofknowledge.com/full_record.do?product=UA&search_mode=GeneralSearch&qid=29&SID=1CAmjdNsnrMlFqXnadP&page=1&doc=1spa
dc.identifier.urihttp://hdl.handle.net/10906/78472-
dc.descriptionMany autoimmune diseases (ADs) share similar underlying pathology and have a tendency to cluster within families, supporting the involvement of shared susceptibility genes. To date, most of the genetic variants associated with systemic lupus erythematosus (SLE) susceptibility also show association with others ADs. ITGAM and its associated 'predisposing' variant (rs1143679, Arg77His), predicted to alter the tertiary structures of the ligand-binding domain of ITGAM, may play a key role for SLE pathogenesis. The aim of this study is to examine whether the ITGAM variant is also associated with other ADs. We evaluated case-control association between rs1143679 and ADs (N=18,457) including primary Sjögren's syndrome, systemic sclerosis, multiple sclerosis, rheumatoid arthritis, juvenile idiopathic arthritis, celiac disease, and type-1 diabetes. We also performed meta-analyses using our data in addition to available published data. Although the risk allele 'A' is relatively more frequent among cases for each disease, it was not significantly associated with any other ADs tested in this study. However, the meta-analysis for systemic sclerosis was associated with rs1143679 (p(meta)=0.008). In summary, this study explored the role of ITGAM in general autoimmunity in seven non-lupus ADs, and only found association for systemic sclerosis when our results were combined with published results. Thus ITGAM may not be a general autoimmunity gene but this variant may be specifically associated with SLE and systemic sclerosis.eng
dc.format.extent4-
dc.format.mediumDigitalspa
dc.language.isoeng-
dc.publisherElsevier-
dc.relation.ispartofAutoimmunity Reviews, Volume 11, Issue 4 - 2012, Pages 276-280-
dc.rightsEL AUTOR, expresa que la obra objeto de la presente autorización es original y la elaboró sin quebrantar ni suplantar los derechos de autor de terceros, y de tal forma, la obra es de su exclusiva autoría y tiene la titularidad sobre éste. PARÁGRAFO: en caso de queja o acción por parte de un tercero referente a los derechos de autor sobre el artículo, folleto o libro en cuestión, EL AUTOR, asumirá la responsabilidad total, y saldrá en defensa de los derechos aquí autorizados; para todos los efectos, la Universidad Icesi actúa como un tercero de buena fe. Esta autorización, permite a la Universidad Icesi, de forma indefinida, para que en los términos establecidos en la Ley 23 de 1982, la Ley 44 de 1993, leyes y jurisprudencia vigente al respecto, haga publicación de este con fines educativos. Toda persona que consulte ya sea la biblioteca o en medio electrónico podrá copiar apartes del texto citando siempre la fuentes, es decir el título del trabajo y el autor.spa
dc.subjectITGAM-
dc.subjectEnfermedades autoinmunesspa
dc.subjectPredisposicion genéticaspa
dc.subjectLupus eritematoso sistémicospa
dc.subjectCiencias socio biomédicasspa
dc.subjectMedical scienceseng
dc.subjectEvaluación genéticaspa
dc.titleEvaluation of genetic association between an ITGAM non-synonymous SNP (rs1143679) and multiple autoimmune diseases.spa
dc.typeinfo:eu-repo/semantics/articleeng
dc.audienceComunidad Universidad Icesi – Investigadoresspa
dc.publisher.facultyFacultad Ciencias de la Saludspa
dc.type.spaArtículospa
dc.publisher.programMedicinaspa
dc.publisher.departmentDepartamento de Ciencias Básicas Médicasspa
dc.coverageAmsterdam de Lat: 52 21 00 N degrees minutes Lat: 52.3500 decimal degrees Long: 004 55 00 E degrees minutes Long: 4.9167 decimal degrees-
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion-
dc.pubplaceAmsterdam-
dc.citation.volume11spa
dc.citation.issue4-
dc.citation.spage276-
dc.citation.epage280-
dc.identifier.doihttp://dx.doi.org/10.1016/j.autrev.2011.07.007-
Appears in Collections:Nuevo conocimiento - BIO

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