Please use this identifier to cite or link to this item: http://repository.icesi.edu.co/biblioteca_digital/handle/10906/79881
Full metadata record
DC FieldValueLanguage
dc.creatorMontoya Peláez, Guillermo Leónspa
dc.date.accessioned2016-08-30T22:01:54Z-
dc.date.available2016-08-30T22:01:54Z-
dc.date.issued2013-09-01-
dc.identifier10.3390/md11124815spa
dc.identifier.issn1660-3397-
dc.identifier.otherhttp://www.mdpi.com/1660-3397/11/12/4815/spa
dc.identifier.urihttp://hdl.handle.net/10906/79881-
dc.descriptionThe marine sponge Ectyoplasia ferox produces antipredatory and allelopathic triterpenoid glycosides as part of its chemical defense repertoire against predators, competitors, and fouling organisms. These molecules are responsible for the pharmacological potential found in the glycosides present in this species. In order to observe the glycochemical diversity present in E. ferox, a liquid chromatography coupled to a tandem mass spectrometry approach to analyse a complex polar fraction of this marine sponge was performed. This gave valuable information for about twenty-five compounds three of which have been previously reported and another three which were found to be composed of known aglycones. Furthermore, a group of four urabosides, sharing two uncommon substitutions with carboxyl groups at C-4 on the terpenoid core, were identified by a characteristic fragmentation pattern. The oxidized aglycones present in this group of saponins can promote instability, making the purification process difficult. Cytotoxicity, cell cycle modulation, a cell cloning efficiency assay, as well as its hemolytic activity were evaluated. The cytotoxic activity was about IC50 40 µg/mL on Jurkat and CHO-k1 cell lines without exhibiting hemolysis. Discussion on this bioactivity suggests the scanning of other biological models would be worthwhile.-
dc.format.extent18 páginas-
dc.format.mediumDigital-
dc.publisherMultidisciplinary Digital Publishing Institutespa
dc.relation.ispartofMarine Drugs, Vol. 11, No. 12 - 2013-
dc.rightsEL AUTOR, expresa que la obra objeto de la presente autorización es original y la elaboró sin quebrantar ni suplantar los derechos de autor de terceros, y de tal forma, la obra es de su exclusiva autoría y tiene la titularidad sobre éste. PARÁGRAFO: en caso de queja o acción por parte de un tercero referente a los derechos de autor sobre el artículo, folleto o libro en cuestión, EL AUTOR, asumirá la responsabilidad total, y saldrá en defensa de los derechos aquí autorizados; para todos los efectos, la Universidad Icesi actúa como un tercero de buena fe. Esta autorización, permite a la Universidad Icesi, de forma indefinida, para que en los términos establecidos en la Ley 23 de 1982, la Ley 44 de 1993, leyes y jurisprudencia vigente al respecto, haga publicación de este con fines educativos. Toda persona que consulte ya sea la biblioteca o en medio electrónico podrá copiar apartes del texto citando siempre la fuentes, es decir el título del trabajo y el autor.-
dc.titleHPLC-ESI-IT-MS/MS Analysis and Biological Activity of Triterpene Glycosides from the Colombian Marine Sponge Ectyoplasia feroxspa
dc.typeinfo:eu-repo/semantics/article-
dc.audienceComunidad Universidad Icesi – Investigadores-
dc.publisher.facultyFacultad de Ciencias Naturales-
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess-
dc.type.spaArtículo-
dc.publisher.programBiología-
dc.publisher.departmentDepartamento de Ciencias Biológicas-
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion-
dc.citation.volume11spa
dc.citation.spage4815-
dc.citation.epage4833-
Appears in Collections:Nuevo conocimiento - NAT

Files in This Item:
File SizeFormat 
montoya_analysis_biologica_2013.pdf857.63 kBAdobe PDFView/Open




This item is licensed under a Creative Commons License Creative Commons