%0 Journal Article 
%T Toxic Epidermal Necrolysis Successfully Treated With Infliximab
%D 2013
%@ 1018-9068
%U http://hdl.handle.net/10906/81261
%X Toxic epidermal necrolysis (TEN) is a life-threatening
drug-induced cutaneous reaction characterized by widespread
apoptosis and detachment of the epidermis. The main causes
of death are secondary infections resulting from epidermal
damage and multiorgan failure [1]. The severity of illness
score (SCORTEN) [2] analyzes 7 independent risk factors
and predicts mortality. Older age, significant comorbidity, and
greater skin involvement correlate with a worse prognosis [2].
The pathogenesis of TEN is unknown. Several studies
suggest that tumor necrosis factor (TNF) α released from
inflammatory cells and activated keratinocytes in the epidermis
plays an important role in the immune response by inducing
direct cytotoxicity and apoptosis [3].
%K Dermatosis
%K Ciencias  socio biomédicas
%K Medical sciences
%K Necrólisis epidérmica tóxica
%K Factor de necrosis tumoral
%K Alergía
%~ GOEDOC, SUB GOETTINGEN