TY  - JOUR 
TI  - Extended Hildebrand Solubility Approach applied to Nimodipine in PEG 400 + ethanol mixtures
PB  - Universidad Nacional de Colombia
PY  - 2013
issn 0034-7418
AB  - Nimodipine (nmd) is a drug used as cerebral vasodilator whose physicochemical
properties in solution have not been studied completely. In this work the Extended
Hildebrand Solubility Approach (ehsa) was applied to evaluate the equilibrium
solubility of nmd in some polyethylene glycol 400 + ethanol mixtures at 298.15 K.
An acceptable correlative capacity of ehsa was found using a regular polynomial
model in order three (overall deviation lower than 1.3%), when the W interaction
parameter is related to the solubility parameter of the mixtures. Moreover, the mean
deviation obtained in the estimated solubility with respect to experimental solubility
was lower than the one obtained directly by means of an empiric regression
in order three of the logarithm experimental solubility as a function of the mixtures’
solubility parameters (1.7%).
KW  - Biology
KW  - Ecology
KW  - Etanol
KW  - Mezclas binarias
KW  - Solubilidad
KW  - Nimodipina,
KW  - Mezclas binarias
KW  - Parámetro de solubilidad.
UR  - http://hdl.handle.net/10906/79889
ER  -