TY  - THES 
TI  - Caracterización de las dispersiones acuosas homogéneas de hidroxipropilmetil celulosa rh y alginato de sodio, empleadas como aglutinantes en la fabricación de productos farmacéuticos granulados de uso veterinario.
PB  - Universidad Icesi
PY  - 2014
UR  - http://hdl.handle.net/10906/76964
AB  - This document represent a research to the aqueous dispersions of two binders at 
different concentrations, Hydroxypropylmethyl Cellulose RH (3 %, 4 %, 5 %, 6 % 
and 7 % w/v) and Sodium alginate (0.5 %, 1 %, 2 % , 3 % and 4 % w/v), in these
were determinated physicochemical characteristics as pH, density (specific weight) 
and viscosity, which were reported in their respective datasheets. As well also, 
establish the performance characteristics of the granulation, through fluidization 
technique for three of the five concentrations studied of the aqueous dispersions of 
each material.
The functionality characteristics or performance about the proposed use as binders 
corresponded to granulometric measurements and the fluidity; this determinations 
were made to the product obtained of granulation process of a diluent commonly 
used, Lactose monohydrate alimentary-grade, with each of the selected binder 
dispersions in a granulator of fluid bed.
Actually, the Pharmaceutical Laboratory Carval Colombia, company dedicated to 
the production and marketing of veterinary pharmaceuticals, is interested in the 
development and production of dosage forms types granulated, which bring on the 
uniform distribution of the product in the mixing of products where they are 
incorporated, ensuring correct dosing of the product, since this prevent the 
segregation of the active ingredient, improve the homogeneity of the mixing 
process, and allow to obtain a product with good flow and a lower percentage of 
fine dusts. All this proof the need of have useful information about the possible use 
of different excipients in a pharmaceutical shape of granulate type, remain central 
the binders.
KW  - Viscosidad
KW  - Farmacéuticos
KW  - Medio acuoso
KW  - Productos farmacéuticos
KW  - Medicamentos farmacéuticos
KW  - Veterinarios
KW  - Trabajos de grado
KW  - Química Farmacéutica
KW  - Departamento de Ciencias Químicas
KW  - Facultad de Ciencias Naturales
KW  - Producción intelectual registrada - Universidad Icesi
ER  -