TY  - THES 
TI  - Estudio termodinámico del fenómeno de asociación entre el polímero clorhidrato de eudragit® e-100 y el sustrato 5hdibenz [b,f] azepine-5-carboxamide en medio acuoso, utilizando el modelo de pseudo-fases poliméricas
PB  - Universidad Icesi
PY  - 2015
UR  - http://hdl.handle.net/10906/77583
AB  - This work is part of a research project of high amplitude, which has focused on the characterization of the physicochemical properties of amphiphilic polymer systems in aqueous solution, in order to evaluate their potential application as novel matrix systems capable of establishing specific interactions with apolar substrates and thus be able to contribute to the improvement of the physicochemical characteristics of these. Specifically, in this study, the degree of association occurred between the polymeric material hydrochloride Eudragit ® E- 100 and the
 substrate apolar 5H - dibenz [ b , f ] azepine -5 -carboxamide was evaluated , using
 the ultrafiltration technique and the pseudo-polymeric phases model. This
 technique involves a process of normal filtration , where cut-off membrane allows
 exclusive pass of the solvent and the substrate is not retained by the polymer
 system , the experimental parameter of measurement can be expressed in terms
 of percent retention ( % R ) , from a relationship between amount of added
 substrate and amount of ultrafiltrate substrate. For this, an ultrafiltration cell fitted  with a cellulose membrane with a pore size of 30,000 Daltons, through which the  passage of solvent and substrate held with the application of 45 psi pressure , in the presence of forced continuous stirring is used.
KW  - Eudragit® E-100
KW  - Industria farmacéutica
KW  - Polímeros
KW  - Medio acuoso
KW  - Trabajos de grado
KW  - Química Farmacéutica
KW  - Departamento de Ciencias Químicas
KW  - Producción intelectual registrada - Universidad Icesi
KW  - Pseudo-polymeric phases model
KW  - Ultrafiltration
KW  - Partition study
ER  -