TY  - JOUR 
TI  - Potential drug delivery system: study of the association of a model nitroimidazole drug with aggregates of amphiphilic polymers on aqueous solution.
PB  - Faculdade de Ciências Farmacêuticas da Universidade de São Paulo
PY  - 2011
issn 1984-8250
AB  - This study evaluated the association of N-hexyl-2-methyl-4-nitroimidazol, a model drug, to aggregates formed by anionic polyelectrolytes on aqueous solution. The alternating copolymers of maleic anhydride and N-vinyl-2-pyrrolidone were synthesized and then modified by reaction of the anhydride groups with aliphatic amines and alcohols of varying length of the alkyl chain. The partition of the model drug between water and the hydrophobic microdomains provided by the copolymers was studied using the pseudo-phase model to determinate the distribution coefficient KS, and the standard free energy of transfer ∆µ°t. The results indicate that all copolymers assessed are potential pharmaceutical reservoirs of the model drug. Nevertheless, the solubility of N-hexyl-2-methyl-4-nitroimidazol on the polymeric solutions is independent from the length of the alkyl chain of the copolymer.
KW  - Biología
KW  - Ecología
KW  - Biology
KW  - Ecology
KW  - Ácido maleico
KW  - Nitroimidazoles
KW  - Polielectrolitos
KW  - Fármacos
UR  - http://hdl.handle.net/10906/79900
ER  -