TY - JOUR TI - Impairment of exogenous lactate clearance in experimental hyperdynamic septic shock is not related to total liver hypoperfusion PB - BioMed Central PY - 2015 issn 1466-609X AB - NTRODUCTION: Although the prognostic value of persistent hyperlactatemia in septic shock is unequivocal, its physiological determinants are controversial. Particularly, the role of impaired hepatic clearance has been underestimated and is only considered relevant in patients with liver ischemia or cirrhosis. Our objectives were to establish whether endotoxemia impairs whole body net lactate clearance, and to explore a potential role for total liver hypoperfusion during the early phase of septic shock. KW - Ciencias socio biomédicas KW - Medical sciences UR - http://hdl.handle.net/10906/80817 ER -