TY - JOUR TI - Simulation-optimization model for production planning in the blood supply chain PB - Springer Verlag PY - 2017 issn 1386-9620 AB - Production planning in the blood supply chain is a challenging task. Many complex factors such as uncertain supply and demand, blood group proportions, shelf life constraints and different collection and production methods have to be taken into account, and thus advanced methodologies are required for decision making. This paper presents an integrated simulation-optimization model to support both strategic and operational decisions in production planning. Discrete-event simulation is used to represent the flows through the supply chain, incorporating collection, production, storing and distribution. KW - Planificación de la producción KW - Cadena de suministro KW - Systems engineering KW - Ingeniería de sistemas y comunicaciones KW - Simulación de modelos KW - Planificación de la producción UR - http://hdl.handle.net/10906/81439 ER -