A rare association of localized scleroderma type morphea, vitiligo, autoimmune hypothyroidism, pneumonitis, autoimmune thrombocytopenic purpura and central nervous system vasculitis. Case report.

Muñoz Buitrón, EvelynOchoa, Carlos D.Cañas Dávila, Carlos AlbertoBonilla Abadía, FabioCarrascal, Edwin2016-02-292016-02-292012-12-201756-0500http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3532086&tool=pmcentrez&rendertype=abstracthttp://download.springer.com/static/pdf/387/art%253A10.1186%252F1756-0500-5-689.pdf?originUrl=http%3A%2F%2Fbmcresnotes.biomedcentral.com%2Farticle%2F10.1186%2F1756-0500-5-689&token2=exp=1478709616~acl=%2Fstatic%2Fpdf%2F387%2Fart%25253A10.1186%25252F1756-0500-5-689.pdf*~hmac=d3be4790122e9ed1059408192b18559a9d5c60e7b0151803736e91f2932169achttp://hdl.handle.net/10906/79015The localized scleroderma (LS) known as morphea, presents a variety of clinical manifestations that can include systemic involvement. Current classification schemes divide morphea into categories based solely on cutaneous morphology, without reference to systemic disease or autoimmune phenomena. This classification is likely incomplete. Autoimmune phenomena such as vitiligo and Hashimoto thyroiditis associated with LS have been reported in some cases suggesting an autoimmune basis. To our knowledge this is the first case of a morphea forming part of a multiple autoimmune syndrome (MAS) and presenting simultaneously with autoimmune thrombocytopenic purpura and central nervous system vasculitis. CASE PRESENTATION: We report an uncommon case of a white 53 year old female patient with LS as part of a multiple autoimmune syndrome associated with pneumonitis, autoimmune thrombocytopenic purpura and central nervous system vasculitis presenting a favorable response with thrombopoietin receptor agonists, pulses of methylprednisolone and cyclophosphamide. CONCLUSION: Is likely that LS have an autoimmune origin and in this case becomes part of MAS, which consist on the presence of three or more well-defined autoimmune diseases in a single patient.5 páginasDigitalapplication/pdfengEL AUTOR, expresa que la obra objeto de la presente autorización es original y la elaboró sin quebrantar ni suplantar los derechos de autor de terceros, y de tal forma, la obra es de su exclusiva autoría y tiene la titularidad sobre éste. PARÁGRAFO: en caso de queja o acción por parte de un tercero referente a los derechos de autor sobre el artículo, folleto o libro en cuestión, EL AUTOR, asumirá la responsabilidad total, y saldrá en defensa de los derechos aquí autorizados; para todos los efectos, la Universidad Icesi actúa como un tercero de buena fe. Esta autorización, permite a la Universidad Icesi, de forma indefinida, para que en los términos establecidos en la Ley 23 de 1982, la Ley 44 de 1993, leyes y jurisprudencia vigente al respecto, haga publicación de este con fines educativos. Toda persona que consulte ya sea la biblioteca o en medio electrónico podrá copiar apartes del texto citando siempre la fuentes, es decir el título del trabajo y el autor.http://creativecommons.org/licenses/by-nc-nd/4.0/A rare association of localized scleroderma type morphea, vitiligo, autoimmune hypothyroidism, pneumonitis, autoimmune thrombocytopenic purpura and central nervous system vasculitis. Case report.info:eu-repo/semantics/openAccesshttp://dx.doi.org/10.1186/1756-0500-5-689Atribución-NoComercial-SinDerivadas 4.0 Internacional (CC BY-NC-ND 4.0)EconomíaEconometríaEconomicsEconometrics modelsVasculitisSistema nervioso centralEnfermedades sistémicasEnfermedades autoinmuneshttp://purl.org/coar/resource_type/c_2df8fbb1instname:Universidad Icesireponame:Biblioteca Digitalrepourl:https://repository.icesi.edu.co/http://purl.org/coar/access_right/c_abf2