Klein, Edwin C.Montoya, Claudia L.Ijzermans, Jan Nicolaas MariaCooper, David KC C.Echeverri Junca, Gabriel JaimeDons, Eefje M.Rigatti, Lora H.Wolf, Roman F.Wágner, Róbert A.2017-03-302017-03-302012-07-011536-4844http://eds.a.ebscohost.com/eds/detail/detail?vid=1&sid=6f8503bc-d924-466a-b500-2aa885ed1a00%40sessionmgr4009&hid=4103&bdata=Jmxhbmc9ZXMmc2l0ZT1lZHMtbGl2ZSZzY29wZT1zaXRl#AN=edselc.2-52.0-84862236367&db=edselchttp://www.pubmedcentral.nih.gov/articlerender.http://hdl.handle.net/10906/81191Collagenous colitis is a chronic inflammatory bowel disease of unknown etiology. It is fairly common in adult humans, but rare in infants, and has been associated with autoimmune disorders. METHODS We report four infant baboons (age 7-12 months) that had received a transplant at 3 months of age and subsequent immunosuppressive therapy for periods of 4-10 months. All presented identical symptoms within a period of 4 weeks, including weight loss associated with chronic watery diarrhea that was unresponsive to standard antimicrobial treatment. RESULTS Clinical chemistry evaluations were within normal ranges, viral causes were ruled out, and fecal and blood cultures were repeatedly negative. At necropsy, two infant baboons were found to have a form of collagenous colitis. In the remaining two baboons that had identical clinical features, immunosuppressive therapy was discontinued and treatment with budesonide was initiated. Both baboons recovered and remained well on no medication until the end of follow-up (24 months).7 páginasDigitalapplication/pdfengEL AUTOR, expresa que la obra objeto de la presente autorización es original y la elaboró sin quebrantar ni suplantar los derechos de autor de terceros, y de tal forma, la obra es de su exclusiva autoría y tiene la titularidad sobre éste. PARÁGRAFO: en caso de queja o acción por parte de un tercero referente a los derechos de autor sobre el artículo, folleto o libro en cuestión, EL AUTOR, asumirá la responsabilidad total, y saldrá en defensa de los derechos aquí autorizados; para todos los efectos, la Universidad Icesi actúa como un tercero de buena fe. Esta autorización, permite a la Universidad Icesi, de forma indefinida, para que en los términos establecidos en la Ley 23 de 1982, la Ley 44 de 1993, leyes y jurisprudencia vigente al respecto, haga publicación de este con fines educativos. Toda persona que consulte ya sea la biblioteca o en medio electrónico podrá copiar apartes del texto citando siempre la fuentes, es decir el título del trabajo y el autor.http://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccesshttp://dx.doi.org/10.1002/ibd.21900Atribución-NoComercial-SinDerivadas 4.0 Internacional (CC BY-NC-ND 4.0)Ciencias socio biomédicasMedical sciencesColitis colagenosaTrasplanteEnfermedades intestinales inflamatoriashttp://purl.org/coar/resource_type/c_2df8fbb1instname:Universidad Icesireponame:Biblioteca Digitalrepourl:https://repository.icesi.edu.co/http://purl.org/coar/access_right/c_abf2