Quintero, AndrésSalamanca Mejia, Constain HugoAdrade, AndrésPineda, Diego2017-07-312017-07-312015-06-01http://ijpsr.com/bft-article/aggregates-of-alternate-amphiphilc-polyanion-to-carry-zwitterionic-drug-in-aqueous-media/http://hdl.handle.net/10906/81885The effect of amphiphilic polyanion Poly(maleic acid-alt-octadecene)sodium salt on solubility of a zwitterionic drug (ampicillin trihydrate) in aqueous media was evaluated. This polymeric salt was obtained by an equimolar reaction of parent copolymer poly Poly(maleic acid-alt-octadecene)with an aqueous solution of NaOH. The obtained amphiphilic polyanion was purified by dialysis and lyophilization and was characterized by FTIR spectroscopy. Secondly, a method for the model drug quantification by UV spectrophotometry at 37°C was standardized. Also the grade of association drug-polymer in aqueous media using ultrafiltration methodology at three levels of temperature (20, 30 and 40°C) and two levels of pH (1.2 and 7.4) was determined. Finally, the variation of aqueous solubility of ampicillin trihydrate in ultra-pure water and two buffer media with pH of 1.2 and 7.4 with an ionic strength of 0.15 M at 37°C in presence and absence of amphiphilic polyanion was evaluated. It was found that maximum solubility is reached at a pH value of 1.2 in absence of polymeric material with a value of 36 mg/mL, which diminishes dramatically to a value of 8.3mg/mL when the polyanion is added. In the other side, when the system has a pH value of 7.4, the drug solubility slightly increases from 13 to 16mg/mL in presence of polymeric material, describing that solubility of this kind of drugs is strongly influenced by aqueous media and this type of polymeric materials.6 páginasDigitalapplication/pdfEnglishEL AUTOR, expresa que la obra objeto de la presente autorización es original y la elaboró sin quebrantar ni suplantar los derechos de autor de terceros, y de tal forma, la obra es de su exclusiva autoría y tiene la titularidad sobre éste. PARÁGRAFO: en caso de queja o acción por parte de un tercero referente a los derechos de autor sobre el artículo, folleto o libro en cuestión, EL AUTOR, asumirá la responsabilidad total, y saldrá en defensa de los derechos aquí autorizados; para todos los efectos, la Universidad Icesi actúa como un tercero de buena fe. Esta autorización, permite a la Universidad Icesi, de forma indefinida, para que en los términos establecidos en la Ley 23 de 1982, la Ley 44 de 1993, leyes y jurisprudencia vigente al respecto, haga publicación de este con fines educativos. Toda persona que consulte ya sea la biblioteca o en medio electrónico podrá copiar apartes del texto citando siempre la fuentes, es decir el título del trabajo y el autor.http://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccesshttp://dx.doi.org/10.13040/IJPSR.0975-8232.6(6).2360-66Atribución-NoComercial-SinDerivadas 4.0 Internacional (CC BY-NC-ND 4.0)Materiales poliméricosTrihidrato de ampicilinaMétodos de investigación en bioquímicaBiochemistry researchhttp://purl.org/coar/resource_type/c_2df8fbb1instname:Universidad Icesireponame:Biblioteca Digitalrepourl:https://repository.icesi.edu.co/http://purl.org/coar/access_right/c_abf2