Diseño y formulación de potenciales formas farmacéuticas de antibióticos beta-lactámicos útiles frente a microorganismos resistentes, caracterización fisicoquímica de la formación de complejos de asociación polimérica entre el antibiótico ampicilina trihidrataday el sistema polimérico Eudragit® E-100"

Abstract

Eudragit® E-100 chloride salt to modify the solubilization thermodynamic properties of ampicillin trihydrate drug in aqueous dissolution media, and thus, to establish its potential as a useful polymeric material for the design of dosage forms of beta- lacatamic antibiotics looking for effectiveness in the treatment of infections caused by antibiotic-resistant microorganisms of this type. Initially, the polymeric material was obtained following standardized methodologies in the research laboratory in physical chemistry at Icesi University, starting with a chemical process of protonation using acid medium. Then, dialysis and lyophilization methodologies were performed to purify the bulk solution. Subsequently, one analytical technique was developed by ultraviolet spectroscopy to quantify ampicillin at study conditions. Furthermore, three methodologies for the aqueous liquid phases saturation were evaluated and standardized, by ampicillin trihydrate, aimed to obtain the intrinsic solubility values of the studied drug. Finally, the effect of the obtained polymeric material on the ampicillin trihydrate intrinsic solubility was tested in absence and presence of the polymeric material. Significant differences were found when such material is present in the solution phase of the drug.