Estandarización de una metodología para la evaluación de los perfiles cinéticos de permeación de fármacos utilizando celdas de Franz a condiciones fisiológicas

Abstract

The problem of acquired resistance form bacteria to antibiotics has an overall incidence, which has caused that many pharmaceutical scientists focus their research on it. The bioprotector polymeric matrices are one of the developed strategies to mitigate it. Over time they have developed some of these matrices for marketing, however these are very expensive and not affordable for many companies. Springing the need for new options of bioprotective matrices with lower costs. The above also leads to the need of run basic physicochemical studies such as kinetic dissolution and permeability profiling studies, which can give an overall characterization of the polymeric matrix behavior on a further application