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Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.contributor.author | Echeverri Junca, Gabriel Jaime | spa |
dc.coverage.spatial | Estados Unidos de Lat: 38 00 00 N degrees minutes Lat: 38.0000 decimal degrees Long: 098 00 00 W degrees minutes Long: -98.0000 decimal degrees | - |
dc.date.accessioned | 2015-10-13T21:05:50Z | - |
dc.date.available | 2015-10-13T21:05:50Z | - |
dc.date.issued | 2012-12-27 | - |
dc.identifier.issn | 1534-6080 | - |
dc.identifier.other | http://journals.lww.com/transplantjournal/pages/results.aspx?fs=%5b%7b%22Operator%22%3a%22and%22%2c%22Field%22%3a%22Title%22%2c%22Key%22%3a%22A+Syndrome+Of+Severe+Hypoglycemia+And+Acidosis+In%22%7d%5d | spa |
dc.identifier.uri | http://hdl.handle.net/10906/78456 | - |
dc.description.abstract | Background: Large animals treated with immunosuppressive drugs for preclinical experiments of transplantation have increased risks of infection, which can be compounded by the induction of diabetes if islet transplantation is planned. Methods: We report our experience with severe sepsis in two young cynomolgus monkeys and five pigs that were subjected to diabetes induction, immunosuppressive therapy, or islet allotransplantation. Results: In two monkeys and five pigs, infection was associated with a syndrome of profound hypoglycemia accompanied by severe acidosis, which was resistant to treatment. We do not believe that this syndrome has been reported previously by others. Conclusions: Despite treatment, this syndrome complicated the interpretation of blood glucose readings as a measure of islet graft function and resulted in death or the need for euthanasia in all seven animals. We tentatively suggest that the syndrome may be related to the presence of microorganisms that metabolize glucose and produce lactate. | eng |
dc.format.extent | 5 páginas | spa |
dc.format.medium | Digital | spa |
dc.format.mimetype | application/pdf | - |
dc.language.iso | spa | spa |
dc.publisher | Wolters Kluwer Health, Inc. | spa |
dc.relation.ispartof | Transplantation, Vol. 94, No12 - 2012 | - |
dc.rights | EL AUTOR, expresa que la obra objeto de la presente autorización es original y la elaboró sin quebrantar ni suplantar los derechos de autor de terceros, y de tal forma, la obra es de su exclusiva autoría y tiene la titularidad sobre éste. PARÁGRAFO: en caso de queja o acción por parte de un tercero referente a los derechos de autor sobre el artículo, folleto o libro en cuestión, EL AUTOR, asumirá la responsabilidad total, y saldrá en defensa de los derechos aquí autorizados; para todos los efectos, la Universidad Icesi actúa como un tercero de buena fe. Esta autorización, permite a la Universidad Icesi, de forma indefinida, para que en los términos establecidos en la Ley 23 de 1982, la Ley 44 de 1993, leyes y jurisprudencia vigente al respecto, haga publicación de este con fines educativos. Toda persona que consulte ya sea la biblioteca o en medio electrónico podrá copiar apartes del texto citando siempre la fuentes, es decir el título del trabajo y el autor. | spa |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | - |
dc.subject | Acidosis, metabolic | eng |
dc.subject | Hypoglycemia | eng |
dc.subject | Infection | eng |
dc.subject | Islet transplantationMonkey | eng |
dc.subject | Ciencias socio biomédicas | spa |
dc.subject | Biomedical sciences | eng |
dc.title | A Syndrome of Severe Hypoglycemia and Acidosis in Young Immunosuppressed Diabetic Monkeys and Pigs—Association With Sepsis | spa |
dc.type | info:eu-repo/semantics/article | spa |
dc.audience | Comunidad Universidad Icesi – Investigadores | spa |
dc.publisher.faculty | Facultad de Ciencias de la salud | spa |
dc.rights.accessrights | info:eu-repo/semantics/openAccess | spa |
dc.publisher.program | Medicina | spa |
dc.publisher.department | Ciencias Básicas Médicas | spa |
dc.creator.email | gjecheverri@icesi.edu.co | spa |
dc.citation.volume | 94 | spa |
dc.citation.issue | 12 | - |
dc.citation.spage | 1187 | - |
dc.citation.epage | 1191 | - |
dc.identifier.doi | http://dx.doi.org/10.1097/TP.0b013e318272210c | - |
dc.rights.license | Atribución-NoComercial-SinDerivadas 4.0 Internacional (CC BY-NC-ND 4.0) | - |
dc.publisher.place | Estados Unidos | spa |
dc.type.coar | http://purl.org/coar/resource_type/c_2df8fbb1 | - |
dc.type.local | Artículo | spa |
dc.identifier.instname | instname: Universidad Icesi | - |
dc.identifier.reponame | reponame: Biblioteca Digital | - |
dc.identifier.repourl | repourl: https://repository.icesi.edu.co/ | - |
dc.rights.coar | http://purl.org/coar/access_right/c_abf2 | - |
dc.type.version | info:eu-repo/semantics/publishedVersion | - |
dc.type.coarversion | http://purl.org/coar/version/c_970fb48d4fbd8a85 | - |
Aparece en las colecciones: | Nuevo conocimiento - BIO |
Ficheros en este ítem:
Fichero | Tamaño | Formato | |
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echeverri_syndrome_severe_2012.pdf | 318.58 kB | Adobe PDF | Visualizar/Abrir |
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