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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Salamanca Mejia, Constain Hugo | spa |
dc.contributor.author | Adrade, Andrés | spa |
dc.contributor.author | Pineda, Diego | spa |
dc.contributor.author | Quintero, Andrés | spa |
dc.coverage.spatial | Panchkula de Lat: 30 43 44 N degrees minutes Lat: 30.7288 decimal degrees Long: 076 56 50 E degrees minutes Long: 76.9472 decimal degrees | - |
dc.date.accessioned | 2017-07-31T01:45:24Z | - |
dc.date.available | 2017-07-31T01:45:24Z | - |
dc.date.issued | 2015-06-01 | - |
dc.identifier.other | http://ijpsr.com/bft-article/aggregates-of-alternate-amphiphilc-polyanion-to-carry-zwitterionic-drug-in-aqueous-media/ | - |
dc.identifier.uri | http://hdl.handle.net/10906/81885 | - |
dc.description.abstract | The effect of amphiphilic polyanion Poly(maleic acid-alt-octadecene)sodium salt on solubility of a zwitterionic drug (ampicillin trihydrate) in aqueous media was evaluated. This polymeric salt was obtained by an equimolar reaction of parent copolymer poly Poly(maleic acid-alt-octadecene)with an aqueous solution of NaOH. The obtained amphiphilic polyanion was purified by dialysis and lyophilization and was characterized by FTIR spectroscopy. Secondly, a method for the model drug quantification by UV spectrophotometry at 37°C was standardized. Also the grade of association drug-polymer in aqueous media using ultrafiltration methodology at three levels of temperature (20, 30 and 40°C) and two levels of pH (1.2 and 7.4) was determined. Finally, the variation of aqueous solubility of ampicillin trihydrate in ultra-pure water and two buffer media with pH of 1.2 and 7.4 with an ionic strength of 0.15 M at 37°C in presence and absence of amphiphilic polyanion was evaluated. It was found that maximum solubility is reached at a pH value of 1.2 in absence of polymeric material with a value of 36 mg/mL, which diminishes dramatically to a value of 8.3mg/mL when the polyanion is added. In the other side, when the system has a pH value of 7.4, the drug solubility slightly increases from 13 to 16mg/mL in presence of polymeric material, describing that solubility of this kind of drugs is strongly influenced by aqueous media and this type of polymeric materials. | eng |
dc.format.extent | 6 páginas | - |
dc.format.medium | Digital | spa |
dc.format.mimetype | application/pdf | eng |
dc.language.iso | English | eng |
dc.relation.ispartof | International Journal of Pharmaceutical Sciences and Research, Vol. 6, No.6- 2015 | - |
dc.rights | EL AUTOR, expresa que la obra objeto de la presente autorización es original y la elaboró sin quebrantar ni suplantar los derechos de autor de terceros, y de tal forma, la obra es de su exclusiva autoría y tiene la titularidad sobre éste. PARÁGRAFO: en caso de queja o acción por parte de un tercero referente a los derechos de autor sobre el artículo, folleto o libro en cuestión, EL AUTOR, asumirá la responsabilidad total, y saldrá en defensa de los derechos aquí autorizados; para todos los efectos, la Universidad Icesi actúa como un tercero de buena fe. Esta autorización, permite a la Universidad Icesi, de forma indefinida, para que en los términos establecidos en la Ley 23 de 1982, la Ley 44 de 1993, leyes y jurisprudencia vigente al respecto, haga publicación de este con fines educativos. Toda persona que consulte ya sea la biblioteca o en medio electrónico podrá copiar apartes del texto citando siempre la fuentes, es decir el título del trabajo y el autor. | spa |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | - |
dc.subject | Materiales poliméricos | spa |
dc.subject | Trihidrato de ampicilina | spa |
dc.subject | Métodos de investigación en bioquímica | - |
dc.subject | Biochemistry research | - |
dc.title | Aggregates of alternate amphiphilc polyanion to carry zwitterionic drug in aquedous media | - |
dc.type | info:eu-repo/semantics/article | eng |
dc.audience | Comunidad Universidad Icesi – Investigadores | spa |
dc.rights.accessrights | info:eu-repo/semantics/openAccess | eng |
dc.creator.email | chsalamanca@icesi.edu.co | - |
dc.citation.volume | 6 | - |
dc.citation.spage | 2360 | - |
dc.citation.epage | 2366 | - |
dc.identifier.doi | http://dx.doi.org/10.13040/IJPSR.0975-8232.6(6).2360-66 | - |
dc.rights.license | Atribución-NoComercial-SinDerivadas 4.0 Internacional (CC BY-NC-ND 4.0) | - |
dc.publisher.place | Panchkula | - |
dc.type.coar | http://purl.org/coar/resource_type/c_2df8fbb1 | - |
dc.type.local | Artículo | spa |
dc.identifier.instname | instname: Universidad Icesi | - |
dc.identifier.reponame | reponame: Biblioteca Digital | - |
dc.identifier.repourl | repourl: https://repository.icesi.edu.co/ | - |
dc.rights.coar | http://purl.org/coar/access_right/c_abf2 | - |
dc.type.version | info:eu-repo/semantics/publishedVersion | eng |
dc.type.coarversion | http://purl.org/coar/version/c_970fb48d4fbd8a85 | - |
Aparece en las colecciones: | Nuevo conocimiento - NAT |
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