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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Parody Rua, Elizabeth | spa |
dc.contributor.author | Tello, Paula M. | spa |
dc.contributor.author | Aguirre, Andrés | spa |
dc.contributor.author | Guevara Cuéllar, César Augusto | spa |
dc.coverage.spatial | Amsterdam de Lat: 52 21 00 N degrees minutes Lat: 52.3500 decimal degrees Long: 004 55 00 E degrees minutes Long: 4.9167 decimal degrees | - |
dc.date.accessioned | 2017-08-14T21:50:59Z | - |
dc.date.available | 2017-08-14T21:50:59Z | - |
dc.date.issued | 2016-12-01 | - |
dc.identifier.issn | 2212-1099 | - |
dc.identifier.other | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84962650951&doi=10.1016%2fj.vhri.2016.01.003&partnerID=40&md5=1b20952ff264363f16408092cb72b1d2 | - |
dc.identifier.uri | http://hdl.handle.net/10906/81941 | - |
dc.description.abstract | Background: Mucopolysaccharidosis (MPS) type II is produced by a deficiency of iduronate-2-sulfatase (I2S). The quantification of the enzyme activity in leukocytes is used as diagnostic confirmation of MPS. Objective: To determinate the cost-effectiveness of the measurement of I2S enzyme activity in leukocytes compared with not carrying out the enzyme activity measurement for diagnostic confirmation of MPS II from the perspective of the Colombian health system. Methods: A cost-effectiveness analysis was conducted on the basis of a decision tree model. The measure of effectiveness was the correct diagnosis of cases of MPS II. The costs of I2S enzymatic quantification in leukocytes, consultation with a geneticist and with other specialists, and costs of diagnostic procedures were included. The time horizon was less than 1 year. A probabilistic sensitivity analysis was performed using Monte-Carlo simulation with 10,000 iterations. Results: The incremental cost was -US $43,145 with an incremental effectiveness of 42 cases. The probabilistic sensitivity analysis confirms the results of basal data, in which the quantification of I2S enzyme activity was less costly and more effective than the alternative. Conclusions: The quantification of I2S enzymatic activity is a dominant technology for the diagnostic confirmation of MPS II, compared with not making the quantification, from the perspective of the Colombian health system. © 2016 International Society for Pharmacoeconomics and Outcomes Research (ISPOR). | - |
dc.format.extent | 6 páginas | spa |
dc.format.medium | Digital | spa |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Elsevier Inc. | - |
dc.relation.ispartof | Value in Health Regional Issues, Vol. 11 -2016 | - |
dc.rights | EL AUTOR, expresa que la obra objeto de la presente autorización es original y la elaboró sin quebrantar ni suplantar los derechos de autor de terceros, y de tal forma, la obra es de su exclusiva autoría y tiene la titularidad sobre éste. PARÁGRAFO: en caso de queja o acción por parte de un tercero referente a los derechos de autor sobre el artículo, folleto o libro en cuestión, EL AUTOR, asumirá la responsabilidad total, y saldrá en defensa de los derechos aquí autorizados; para todos los efectos, la Universidad Icesi actúa como un tercero de buena fe. Esta autorización, permite a la Universidad Icesi, de forma indefinida, para que en los términos establecidos en la Ley 23 de 1982, la Ley 44 de 1993, leyes y jurisprudencia vigente al respecto, haga publicación de este con fines educativos. Toda persona que consulte ya sea la biblioteca o en medio electrónico podrá copiar apartes del texto citando siempre la fuentes, es decir el título del trabajo y el autor. | spa |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | - |
dc.subject | Síndrome de Hunter | spa |
dc.subject | Mucopolisacaridosis | spa |
dc.subject | Biología | spa |
dc.subject | Biology | eng |
dc.subject | Biochemistry research | eng |
dc.title | Cost-Effectiveness of the Quantification of Enzymatic Activity in Leukocytes in Comparison to Its Nonrealization for a Rare Disease in Latin America: The Case of Mucopolysaccharidosis Type II in Colombia | - |
dc.type | info:eu-repo/semantics/article | - |
dc.publisher.faculty | Facultad de Ciencias Naturales | spa |
dc.rights.accessrights | Info:eu-repo/semantics/restrictedAccess | - |
dc.publisher.department | Departamento de Ciencias Biológicas | spa |
dc.citation.volume | 11 | - |
dc.citation.spage | 42 | - |
dc.citation.epage | 48 | - |
dc.identifier.doi | http://dx.doi.org/10.1016/j.vhri.2016.01.003 | - |
dc.rights.license | Atribución-NoComercial-SinDerivadas 4.0 Internacional (CC BY-NC-ND 4.0) | - |
dc.publisher.place | Ámsterdam | - |
dc.type.coar | http://purl.org/coar/resource_type/c_2df8fbb1 | - |
dc.type.local | Artículo | spa |
dc.identifier.instname | instname: Universidad Icesi | - |
dc.identifier.reponame | reponame: Biblioteca Digital | - |
dc.identifier.repourl | repourl: https://repository.icesi.edu.co/ | - |
dc.type.version | info:eu-repo/semantics/publishedVersion | - |
dc.type.coarversion | http://purl.org/coar/version/c_970fb48d4fbd8a85 | - |
Aparece en las colecciones: | Nuevo conocimiento - NAT |
Ficheros en este ítem:
Fichero | Tamaño | Formato | |
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parody_cost_effectiveness_2016.pdf | 998.92 kB | Adobe PDF | Visualizar/Abrir |
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