Estudio termodinámico del fenómeno de asociación entre el polímero clorhidrato de eudragit® e-100 y el sustrato 5hdibenz [b,f] azepine-5-carboxamide en medio acuoso, utilizando el modelo de pseudo-fases poliméricas

Abstract

This work is part of a research project of high amplitude, which has focused on the characterization of the physicochemical properties of amphiphilic polymer systems in aqueous solution, in order to evaluate their potential application as novel matrix systems capable of establishing specific interactions with apolar substrates and thus be able to contribute to the improvement of the physicochemical characteristics of these. Specifically, in this study, the degree of association occurred between the polymeric material hydrochloride Eudragit ® E- 100 and the substrate apolar 5H - dibenz [ b , f ] azepine -5 -carboxamide was evaluated , using the ultrafiltration technique and the pseudo-polymeric phases model. This technique involves a process of normal filtration , where cut-off membrane allows exclusive pass of the solvent and the substrate is not retained by the polymer system , the experimental parameter of measurement can be expressed in terms of percent retention ( % R ) , from a relationship between amount of added substrate and amount of ultrafiltrate substrate. For this, an ultrafiltration cell fitted with a cellulose membrane with a pore size of 30,000 Daltons, through which the passage of solvent and substrate held with the application of 45 psi pressure , in the presence of forced continuous stirring is used.