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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Echeverri Junca, Gabriel Jaime | spa |
dc.coverage.spatial | Estados Unidos de Lat: 25 07 00 N degrees minutes Lat: 25.1167 decimal degrees Long: 100 28 00 W degrees minutes Long: -100.4667 decimal degrees | spa |
dc.date.accessioned | 2016-12-05T20:20:59Z | - |
dc.date.available | 2016-12-05T20:20:59Z | - |
dc.date.issued | 2012-01-11 | - |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.other | http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0029720 | - |
dc.identifier.uri | http://hdl.handle.net/10906/80893 | - |
dc.description.abstract | Orthotopic liver transplantation was carried out in baboons using wild-type (WT, n = 1) or genetically-engineered pigs (a1,3- galactosyltransferase gene-knockout, GTKO), n = 1; GTKO pigs transgenic for human CD46, n = 7) and a clinically-acceptable immunosuppressive regimen. Biopsies were obtained from the WT pig liver pre-Tx and at 30 min, 1, 2, 3, 4 and 5 h posttransplantation. Biopsies of genetically-engineered livers were obtained pre-Tx, 2 h after reperfusion and at necropsy (4–7 days after transplantation). Tissues were examined by light, confocal, and electron microscopy. All major native organs were also examined. The WT pig liver underwent hyperacute rejection. After genetically-engineered pig liver transplantation, hyperacute rejection did not occur. Survival was limited to 4–7 days due to repeated spontaneous bleeding in the liver and native organs (as a result of profound thrombocytopenia) which necessitated euthanasia. At 2 h, graft histology was largely normal. At necropsy, genetically-engineered pig livers showed hemorrhagic necrosis, platelet aggregation, platelet-fibrin thrombi, monocyte/macrophage margination mainly in liver sinusoids, and vascular endothelial cell hypertrophy, confirmed by confocal and electron microscopy. Immunohistochemistry showed minimal deposition of IgM, and almost absence of IgG, C3, C4d, C5b-9, and of a cellular infiltrate, suggesting that neither antibody- nor cell-mediated rejection played a major role. | spa |
dc.format.extent | 11 páginas | spa |
dc.format.medium | Digital | spa |
dc.language.iso | spa | spa |
dc.publisher | Public Library of Science | spa |
dc.relation.ispartof | PLoS ONE, Vol. 7 No. 1 -2012 | - |
dc.rights | EL AUTOR, expresa que la obra objeto de la presente autorización es original y la elaboró sin quebrantar ni suplantar los derechos de autor de terceros, y de tal forma, la obra es de su exclusiva autoría y tiene la titularidad sobre éste. PARÁGRAFO: en caso de queja o acción por parte de un tercero referente a los derechos de autor sobre el artículo, folleto o libro en cuestión, EL AUTOR, asumirá la responsabilidad total, y saldrá en defensa de los derechos aquí autorizados; para todos los efectos, la Universidad Icesi actúa como un tercero de buena fe. Esta autorización, permite a la Universidad Icesi, de forma indefinida, para que en los términos establecidos en la Ley 23 de 1982, la Ley 44 de 1993, leyes y jurisprudencia vigente al respecto, haga publicación de este con fines educativos Todo persona que consulte ya sea la biblioteca o en medio electrónico podrá copiar apartes del texto citando siempre la fuentes, es decir el título del trabajo y el autor. | spa |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | - |
dc.subject | Ciencias socio biomédicas | spa |
dc.subject | Medical sciences | spa |
dc.subject | Ingeniería genética | - |
dc.subject | Trasplante hepatico | - |
dc.subject | biopsias | - |
dc.title | Genetically-Engineered Pig-to-Baboon Liver Xenotransplantation: Histopathology of Xenografts and Native Organs | spa |
dc.type | info:eu-repo/semantics/article | spa |
dc.audience | Comunidad Universidad Icesi - Investigadores | spa |
dc.publisher.faculty | Facultad de Ciencias de la Salud | spa |
dc.rights.accessrights | info:eu-repo/semantics/openAccess | spa |
dc.publisher.program | Medicina | spa |
dc.publisher.department | Departamento Ciencias Básicas Médicas | spa |
dc.coverage | San Faustino de Lat: 32 13 00 N degrees minutes Lat: 32.2167 decimal degrees Long: 116 10 10 W degrees minutes Long: -116.1694 decimal degrees | - |
dc.citation.volume | 7 | spa |
dc.citation.issue | 1 | spa |
dc.citation.spage | 1 | spa |
dc.citation.epage | 11 | spa |
dc.identifier.doi | https://doi.org/10.1371/journal.pone.0029720 | - |
dc.rights.license | Atribución-NoComercial-SinDerivadas 4.0 Internacional (CC BY-NC-ND 4.0) | - |
dc.publisher.place | San Francisco | spa |
dc.type.coar | http://purl.org/coar/resource_type/c_2df8fbb1 | - |
dc.type.local | Artículo | spa |
dc.identifier.instname | instname: Universidad Icesi | - |
dc.identifier.reponame | reponame: Biblioteca Digital | - |
dc.identifier.repourl | repourl: https://repository.icesi.edu.co/ | - |
dc.rights.coar | http://purl.org/coar/access_right/c_abf2 | - |
dc.type.version | info:eu-repo/semantics/publishedVersion | spa |
dc.type.coarversion | http://purl.org/coar/version/c_970fb48d4fbd8a85 | - |
Aparece en las colecciones: | Nuevo conocimiento - BIO |
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Fichero | Descripción | Tamaño | Formato | |
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echeverri_genetically_engineer_2012.pdf | 1.18 MB | Adobe PDF | Visualizar/Abrir |
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