Curso clínico de pacientes de trasplante autógeno de médula ósea portadores del virus linfotrópico humano

Abstract

Human T-lymphotropic virus 1 infection is common in Colombia's Pacific coast and has been linked to adult T-cell leukemia/lymphoma and human T-lymphotropic virus 1-associated myelopathy in a low percentage of cases. In patients with solid organ transplantation, these diseases occur more quickly than in other scenarios but in bone marrow transplantation the true impact is unknown. We describe 3 seropositive patients with lymphoma who underwent autologous stem cell transplantation; in one case there was relapse of the hematologic malignancy and death occurred as a result. Another patient had symptoms compatible with human T-lymphotropic virus 1-associated myelopathy and the last patient had a graft vs. host disease. In seropositive people who need hematopoietic cell transplantation, an active search for this virus is required to be able to follow and assess the virus's impact on outcomes, as well as to assess whether the evolution could change according to the transplant conditioning regimen.