Examinando por Autor "Aguilar de Plata, Cecilia"

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Impact of oxidative stress during pregnancy on fetal epigenetic patterns and early origin of vascular diseases.
(The Oxford University Press, 2015-01-01) Castillo Giraldo, Andres Orlando
Epidemiological studies have led scientists to postulate the developmental origins of health and disease hypothesis for noncommunicable diseases such as diabetes, cardiovascular diseases, hypertension, and obesity. However, the cellular and molecular mechanisms involved in the development of these diseases are not well understood. In various animal models, it has been observed that oxidative stress during pregnancy is associated with the early development of endothelial dysfunction in offspring. This phenomenon suggests that endothelial dysfunction may initiate in the uterus and could lead to increased risk of cardiovascular disease later in life. Currently, it is known that many of the fetal adaptive responses to environmental factors are mediated by epigenetic changes in the genome, especially by the degree of methylation in cytosines in the promoter regions of genes. These findings suggest that the establishment of a particular epigenetic pattern in the genome may be generated by oxidative stress.
Relationship between maternal and newborn endothelial function and oxidative stress
(Wiley, 2015-12-01) Echeverri, Isabella; Aguilar de Plata, Cecilia; Mateous, Julio César; Suárez Ortegon, Milton Fabian; Mosquera, Mildrey; Ortega Ávila, José Guillermo; Castillo Giraldo, Andrés Orlando; Jiménez, Eliécer
Objective To evaluate the Relationship between maternal and newborn endothelial function and oxidative stress. Methods Forty-three pregnant women and their offspring were evaluated. As markers of endothelial function, the flow-mediated dilation (FMD) was measured in pregnant women in the second and third trimesters, and nitric oxide (NO) was quantified in the endothelial cells of the umbilical cord vein. Malondialdehyde (MDA), as a marker of oxidative stress, was measured in the maternal plasma (second and third trimesters) and plasma from umbilical cord blood. Gestational age and birth weight were recorded. Correlations between variables were estimated, and adjustments were made for specific gestational week of measurement, gestational age at birth, and complications during pregnancy and/or at delivery.