Examinando por Autor "Mora Guerrero, Carolina Del Pilar"

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Especies vegetales del Valle del Cauca con uso potencial en investigación fitoquímica Facultad de Ciencias Naturales – Universidad Icesi
(Universidad Icesi, 2011-03-31) Mora Guerrero, Carolina Del Pilar
Colombia es uno de los países con mayor biodiversidad en el mundo, donde el Valle del Cauca se encuentra entre las regiones colombianas con mayor diversidad de plantas, muchas de las cuales tienen un alto potencial para el desarrollo de la medicina o la industria farmacéutica. Por lo anterior, el presente trabajo está enfocado en identificar especies Vegetales con uso potencial que puedan ser incorporadas a proyectos de investigación en fitoquímica, así como en definir alternativas viables para su conservación. De esta forma, se han identificado 35 especies de plantas (nativas o naturalizadas)del Valle del Cauca y regiones circunvecinas, para uso medicinal, cosmético, industrial, entre otros.
Estimation of the indomethacin solubility in ethanol + water mixtures by the extended Hildebrand solubility approach - Open Access Library
(Universidad Nacional de Colombia, 2010-06-01) Mora Guerrero, Carolina Del Pilar
indomethacin (imc) is an analgesic drug whose physicochemical properties have not been thoroughly studied. in this work the extended hildebrand solubility approach (ehsa) was applied to evaluate the solubility of imc in ethanol + water mixtures at 298.15 k. an acceptable correlative capacity of ehsa was found using a regular polynomial model in order four (overall deviation lower than 4.1%), when the w interaction parameter is related to the solubility parameter of the mixtures. besides, the deviations obtained in the estimated solubility with respect to experimental solubility were lower compared with those obtained directly by means of an empiric regression of the experimental solubility as a function of the mixtures′ solubility parameters.
Extended Hildebrand Solubility Approach applied to Nimodipine in PEG 400 + ethanol mixtures
(Universidad Nacional de Colombia, 2013-01-01) Mora Guerrero, Carolina Del Pilar
Nimodipine (nmd) is a drug used as cerebral vasodilator whose physicochemical properties in solution have not been studied completely. In this work the Extended Hildebrand Solubility Approach (ehsa) was applied to evaluate the equilibrium solubility of nmd in some polyethylene glycol 400 + ethanol mixtures at 298.15 K. An acceptable correlative capacity of ehsa was found using a regular polynomial model in order three (overall deviation lower than 1.3%), when the W interaction parameter is related to the solubility parameter of the mixtures. Moreover, the mean deviation obtained in the estimated solubility with respect to experimental solubility was lower than the one obtained directly by means of an empiric regression in order three of the logarithm experimental solubility as a function of the mixtures’ solubility parameters (1.7%).
Thermodynamics of mixing of sodium naproxen and procaine hydrochloride in ethanol + water cosolvent mixtures
(Universidad Nacional de Colombia, 2010-07-01) Mora Guerrero, Carolina Del Pilar
Thermodynamic functions Gibbs energy, enthalpy, and entropy of mixing of sodium naproxen and procaine hydrochloride were evaluated. Mixing quantities were calculated based on fusion calorimetric values obtained from differential scanning calorimetry measurements and equilibrium solubility values reported in the literature for both drugs in ethanol + water mixtures. By means of enthalpy-entropy compensation analysis, non-linear ΔH°mix vs. ΔG°mix plots were obtained which indicates different mechanisms involved in the dissolution of these drugs according to mixtures composition. Nevertheless, the molecular and ionic events involved in the dissolution of this drug in this cosolvent system are unclear.