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FCN- Natura

URI permanente para esta comunidadhttp://hdl.handle.net/10906/78190

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Examinando FCN- Natura por Materia "Alzheimer (Enfermedad neurodegenerativa)"

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    Ítem
    Amyloid-beta immunotherapy: the hope for Alzheimer disease?
    (Universidad del Valle, 2016-10-01) Lopera, Francisco
    Alzheimer disease (AD) is the most prevalent form of dementia of adult-onset, characterized by progressive impairment in cognition and memory. There is no cure for the disease and the current treatments are only symptomatic. Drug discovery is an expensive and time-consuming process; in the last decade no new drugs have been found for AD despite the efforts of the scientific community and pharmaceutical companies. The Aβ immunotherapy is one of the most promising approaches to modify the course of AD. This therapeutic strategy uses synthetic peptides or monoclonal antibodies (mAb) to decrease the Aβ load in the brain and slow the progression of the disease. Therefore, this article will discuss the main aspects of AD neuropathogenesis, the classical pharmacologic treatment, as well as the active and passive immunization describing drug prototypes evaluated in different clinical trials.
  • Miniatura
    Ítem
    Cultivo in vitro de tejidos vegetales de plantas de la familia amaryllidaceae.
    (Universidad Icesi, 2014-01-01) Reyes Moreno, Jorge Emilio; Santaella Tenorio, Marcela; Asesor Tesis; Asesor Tesis
    The plants family Amaryllidaceae has broad pharmaceutical interest due to its content of alkaloids with different therapeutic activities. From the alkaloids found in this family mainly stands galantamine, which is used for the palliative treatment of Alzheimer's disease. In Colombia, particularly in the Valle del Cauca, some of the species belonging to this family are threatened due to habitat destruction. It is therefore important to develop methodologies to preserve these species, using strategies such as the establishment of ex situ germplasm banks. The establishment of this germplasm bank can be achieved in a controlled manner, using in vitro culture techniques such as clonal propagation of plants, also called micropropagation.