Costimulation blockade in pig artery patch xenotransplantation - a simple model to monitor the adaptive immune response in nonhuman primates.
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2012-07-01
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Wiley
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BACKGROUND: CD154 blockade-based immunosuppression successfully prevents both humoral and cellular adaptive immune responses in baboons receiving α1,3-galactosyltransferase gene-knockout (GTKO) pig organs. Using a GTKO pig artery transplantation model in baboons, we evaluated the efficacy of CD28/B7 costimulatory pathway blockade in comparison with CD154 blockade.
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Ciencias socio biomédicas, Anticuerpos, Trasplante, Arteria, Xenotrasplantes
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Medical sciences,
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http://dx.doi.org/10.1111/j.1399-3089.2012.00711.x
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0908-665X
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