Grandes dosis de corticoides sistémicos en pacientes con síndrome de Stevens--Johnson y necrólisis epidérmica tóxica: descripción de siete casos y revisión de la literatura.

Abstract

Introduction: Stevens- Johnson (SJS) and Toxic Epidermal Necrolysis (TEN) are considered to be the same diseases but of different severities across a spectrum; they are severe drug reactions characterized by a progressive involvement of skin and mucous membranes, caused by alterations in the immune response. Despite multiples advances in knowledge of the physiopathology of this disease, to date there is no pharmacological treatment with enough clinical evidence to be called a standard treatment. Glucocorticosteroids are one of the treatments used for SJS and TEN with different results among the published literature.This paper pretends to describe our experience with high dose of glucocorticosteroids for the treatment of SJS and TEN.