Physicochemical characterization of in situ drug-polymer nanocomplex formed between zwitterionic drug and ionomeric material in aqueous solution
| dc.audience | Editor | spa |
| dc.citation.issue | 1 | |
| dc.citation.volume | 72 | |
| dc.contributor.author | Villada, Juan D. | spa |
| dc.coverage.spatial | Netherlands de Lat: 52 30 00 N degrees minutes Lat: 52.5000 decimal degrees Long: 005 45 00 E degrees minutes Long: 5.7500 decimal degrees | spa |
| dc.creator.email | chsalamanca@icesi.edu.co | spa |
| dc.date.accessioned | 2017-05-17T22:36:36Z | |
| dc.date.available | 2017-05-17T22:36:36Z | |
| dc.date.issued | 2017-03-01 | |
| dc.description.abstract | Biocompatible polymeric materials with the potential to form functional structures, in association with different therapeutic molecules, in physiological media, represent a great potential for biological and pharmaceutical applications. Therefore, here the formation of a nano-complex between a synthetic cationic polymer and model drug (ampicillin trihydrate) was studied. The formed complex was characterized by size and zeta potential measurements, using dynamic light scattering and capillary electrophoresis. Moreover, the chemical and thermodynamically stability of these complexes were studied. The ionomeric material, here referred as EuCl, was obtained by equimolar reaction between Eudragit E and HCl. The structural characterization was carried out by potentiometric titration, FTIR spectroscopy, and DSC. The effect of pH, time, polymer concentration and ampicillin/polymer molar ratio over the hydrodynamic diameter and zeta potential were established | spa |
| dc.format.extent | 9 páginas | spa |
| dc.format.medium | Digital | spa |
| dc.identifier | 10.1016/j.msec.2016.11.097 | |
| dc.identifier.doi | https://doi.org/10.1016/j.msec.2016.11.097 | |
| dc.identifier.instname | instname:Universidad Icesi | |
| dc.identifier.issn | 0928-4931 | |
| dc.identifier.other | https://nebulosa.icesi.edu.co:2615/record/display.uri?eid=2-s2.0-84998865167&origin=resultslist&sort=plf-f&src=s&st1=icesi&nlo=&nlr=&nls=&sid=146634F6FFD209F746C330D4F0C3D082.wsnAw8kcdt7IPYLO0V48gA%3a110&sot=b&sdt=cl&cluster=scopubyr%2c%222017%22%2ct&sl=12&s=AFFIL%28icesi%29&relpos=2&citeCnt=0&searchTerm= | |
| dc.identifier.reponame | reponame:Biblioteca Digital | |
| dc.identifier.repourl | repourl:https://repository.icesi.edu.co/ | |
| dc.identifier.uri | http://hdl.handle.net/10906/81447 | |
| dc.language.iso | eng | spa |
| dc.publisher | Elsevier | spa |
| dc.publisher.department | Departamento de Ciencias Químicas | spa |
| dc.publisher.faculty | Facultad de Ciencias Naturales | spa |
| dc.publisher.place | Netherlands | spa |
| dc.publisher.program | Química con énfasis en Bioquimica | spa |
| dc.relation.citationendpage | 414 | |
| dc.relation.citationstartpage | 405 | |
| dc.relation.ispartof | Materials Science and Engineering: C, Vol. 72, No.1 - 2017 | |
| dc.rights | EL AUTOR, expresa que la obra objeto de la presente autorización es original y la elaboró sin quebrantar ni suplantar los derechos de autor de terceros, y de tal forma, la obra es de su exclusiva autoría y tiene la titularidad sobre éste. PARÁGRAFO: en caso de queja o acción por parte de un tercero referente a los derechos de autor sobre el artículo, folleto o libro en cuestión, EL AUTOR, asumirá la responsabilidad total, y saldrá en defensa de los derechos aquí autorizados; para todos los efectos, la Universidad Icesi actúa como un tercero de buena fe. Esta autorización, permite a la Universidad Icesi, de forma indefinida, para que en los términos establecidos en la Ley 23 de 1982, la Ley 44 de 1993, leyes y jurisprudencia vigente al respecto, haga publicación de este con fines educativos Todo persona que consulte ya sea la biblioteca o en medio electrónico podrá copiar apartes del texto citando siempre la fuentes, es decir el título del trabajo y el autor. | spa |
| dc.rights.accessrights | info:eu-repo/semantics/openAccess | spa |
| dc.rights.coar | http://purl.org/coar/access_right/c_abf2 | |
| dc.rights.license | Atribución-NoComercial-SinDerivadas 4.0 Internacional (CC BY-NC-ND 4.0) | |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | |
| dc.subject.proposal | Polimeros cationicos | spa |
| dc.subject.proposal | Medicamentos | spa |
| dc.subject.proposal | Materiales poliméricos | spa |
| dc.subject.proposal | Farmacéutica | spa |
| dc.subject.proposal | Métodos de investigación en bioquímica | spa |
| dc.subject.proposal | Biodiversity conservation | spa |
| dc.title | Physicochemical characterization of in situ drug-polymer nanocomplex formed between zwitterionic drug and ionomeric material in aqueous solution | spa |
| dc.type.coar | http://purl.org/coar/resource_type/c_2df8fbb1 | |
| dc.type.coarversion | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |
| dc.type.driver | info:eu-repo/semantics/article | spa |
| dc.type.local | Artículo | spa |
| dc.type.version | info:eu-repo/semantics/publishedVersion | spa |
