AngiomiRs: Potential Biomarkers of Pregnancy's Vascular Pathologies

No hay miniatura disponible

Fecha

2015-01-01

Director de tesis/Asesor

Título de la revista

ISSN de la revista

Título del volumen

Publicador

Hindawi Publishing Corporation

Editor

Compartir

Documentos PDF

Resumen

In recent years, microRNAs (miRNAs) have been the focus of research for their role in posttranscriptional regulation and as potential biomarkers of risk for disease development. Their identification in specific physiological processes, like angiogenesis, a key pathway in placental vascular development in pregnancy, suggests an important role of miRNAs that regulate angiogenesis (angiomiRs). Many complications of pregnancy have in common placental vascular alterations, involving an imbalance in the angiogenesis process in the development of conditions such as preeclampsia, intrauterine growth restriction, and gestational diabetes, complications with the highest rates of morbimortality in pregnancy. Many studies have identified angiomiRs with differential expression profiles in each of these diseases; however, this evidence requires further studies focused on evaluating their potential as biomarkers of risk for the angiomiRs detected, to establish correlations between placental tissue and serum/plasma expression profiles. Therefore, the objective of this review is to highlight the best angiomiRs detected in placental tissue and serum/plasma in each of these three pathologies to show the current data available for potential biomarkers and to propose future research strategies on this topic. © 2015 Laura María Rodríguez Santa et al.

Descripción

Palabras clave

Citación

ARK

ARXIV

Barcode

Bibcode

EAN13

DOI

http://dx.doi.org/10.1155/2015/320386

EISSN

GOVDOC

Handle

IGSN

ISBN

ISMN

ISSN

2090-2727

ISTC

ISSN-L

LSID

Local

Other

https://www.scopus.com/inward/record.uri?eid=2-s2.0-84946019749&doi=10.1155%2f2015%2f320386&partnerID=40&md5=88eb7fab6f05bb8415ea6e10de408cfe

OLIB

PISSN

PMID

PURL

SICI

Slug

SoundCloud

UPC

URL

URN

YouTube

WOS