Structural characterization and anti-aging activity of a novel extracellular polysaccharide from fungus Phellinus sp. in a mammalian system
dc.audience | Comunidad Universidad Icesi | spa |
dc.citation.issue | 8 | |
dc.citation.volume | 7 | |
dc.contributor.author | Peterson, Eric Charles | spa |
dc.coverage.spatial | Cambridge de Lat: 52 12 00 N degrees minutes Lat: 52.2000 decimal degrees Long: 000 07 00 E degrees minutes Long: 0.1167 decimal degrees | |
dc.date.accessioned | 2017-12-15T15:14:02Z | |
dc.date.available | 2017-12-15T15:14:02Z | |
dc.date.issued | 2016-08-01 | |
dc.description.abstract | Little is known about the chemical structure of purified extracellular polysaccharides from Phellinus sp., a fungal species with known medicinal properties. A combination of IR spectroscopy, methylation analysis and NMR were performed for the structural analysis of a purified extracellular polysaccharide derived from Phellinus sp. culture, denoted as SHP-1, along with an evaluation of the anti-aging effect in vivo of the polysaccharide supplementation. The structure of SHP-1 was established, with a backbone composed of →2,4)-α-d-glucopyranose-(1→ and →2)-β-d-mannopyranose-(1→ and two terminal glucopyranose branches. Biochemical analysis from mammalian animal experiments demonstrated that SHP-1 possesses the ability to enhance antioxidant enzyme activities, such as catalase (CAT) and superoxide dismutase (SOD) activities, Trolox equivalent antioxidant capacity (TEAC) in serum of d-galactose-aged mice, while reducing lipofuscin levels, another indicator of cell aging, indicating a potential association with anti-aging activities in a dose dependent manner. This compound had a favourable influence on immune organ indices, and a marked amelioration ability of histopathological hepatic lesions such as necrosis, karyolysis and reduced inflammation and apoptosis in mouse hepatocytes. These results suggest that SHP-1 has strong antioxidant activities and a significant protective effect against oxidative stress or hepatotoxicity induced by d-galactose in mice and it could be developed as a food ingredient or a pharmaceutical to prevent many age-associated diseases such as major depressive disorder and hepatotoxicity. To our knowledge, this is the first report on the antioxidant effects of a novel purified exopolysaccharide derived from Phellinus sp. © 2016 The Royal Society of Chemistry. | spa |
dc.format.extent | 12 páginas | spa |
dc.format.medium | Digital | spa |
dc.format.mimetype | application/pdf | |
dc.identifier.doi | https://doi.org/10.1039/C6FO00422A | |
dc.identifier.instname | instname:Universidad Icesi | |
dc.identifier.issn | 2042-6496 | |
dc.identifier.other | http://xlink.rsc.org/?DOI=C6FO00422A | |
dc.identifier.reponame | reponame:Biblioteca Digital | |
dc.identifier.repourl | repourl:https://repository.icesi.edu.co/ | |
dc.identifier.uri | http://hdl.handle.net/10906/82416 | |
dc.language.iso | eng | eng |
dc.publisher | Royal Society of Chemistry | |
dc.publisher.department | Departamento de Ingeniería Industrial | spa |
dc.publisher.faculty | Facultad de Ingeniería | spa |
dc.publisher.place | Cambridge | |
dc.publisher.program | Ingeniería Industrial | spa |
dc.relation.citationendpage | 3479 | |
dc.relation.citationstartpage | 3468 | |
dc.relation.ispartof | Food and Function, Vol. 7, No. 8 - 2016 | |
dc.rights | EL AUTOR, expresa que la obra objeto de la presente autorización es original y la elaboró sin quebrantar ni suplantar los derechos de autor de terceros, y de tal forma, la obra es de su exclusiva autoría y tiene la titularidad sobre éste. PARÁGRAFO: en caso de queja o acción por parte de un tercero referente a los derechos de autor sobre el artículo, folleto o libro en cuestión, EL AUTOR, asumirá la responsabilidad total, y saldrá en defensa de los derechos aquí autorizados; para todos los efectos, la Universidad Icesi actúa como un tercero de buena fe. Esta autorización, permite a la Universidad Icesi, de forma indefinida, para que en los términos establecidos en la Ley 23 de 1982, la Ley 44 de 1993, leyes y jurisprudencia vigente al respecto, haga publicación de este con fines educativos Todo persona que consulte ya sea la biblioteca o en medio electrónico podrá copiar apartes del texto citando siempre la fuentes, es decir el título del trabajo y el autor. | spa |
dc.rights.accessrights | info:eu-repo/semantics/openAccess | eng |
dc.rights.coar | http://purl.org/coar/access_right/c_abf2 | |
dc.rights.license | Atribución-NoComercial-SinDerivadas 4.0 Internacional (CC BY-NC-ND 4.0) | |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.subject.proposal | Alimentos - Análisis | spa |
dc.subject.proposal | Nutrición | spa |
dc.subject.proposal | Antioxidantes | spa |
dc.subject.proposal | Análisis bioquímico | spa |
dc.subject.proposal | Enzimas | spa |
dc.subject.proposal | Ingeniería de producción | spa |
dc.subject.proposal | Production engineering | eng |
dc.title | Structural characterization and anti-aging activity of a novel extracellular polysaccharide from fungus Phellinus sp. in a mammalian system | |
dc.type.coar | http://purl.org/coar/resource_type/c_2df8fbb1 | |
dc.type.coarversion | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |
dc.type.driver | info:eu-repo/semantics/article | eng |
dc.type.local | Artículo | spa |
dc.type.version | info:eu-repo/semantics/publishedVersion | eng |
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