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Structural characterization and anti-aging activity of a novel extracellular polysaccharide from fungus Phellinus sp. in a mammalian system

dc.audienceComunidad Universidad Icesispa
dc.citation.issue8
dc.citation.volume7
dc.contributor.authorPeterson, Eric Charlesspa
dc.coverage.spatialCambridge de Lat: 52 12 00 N degrees minutes Lat: 52.2000 decimal degrees Long: 000 07 00 E degrees minutes Long: 0.1167 decimal degrees
dc.date.accessioned2017-12-15T15:14:02Z
dc.date.available2017-12-15T15:14:02Z
dc.date.issued2016-08-01
dc.description.abstractLittle is known about the chemical structure of purified extracellular polysaccharides from Phellinus sp., a fungal species with known medicinal properties. A combination of IR spectroscopy, methylation analysis and NMR were performed for the structural analysis of a purified extracellular polysaccharide derived from Phellinus sp. culture, denoted as SHP-1, along with an evaluation of the anti-aging effect in vivo of the polysaccharide supplementation. The structure of SHP-1 was established, with a backbone composed of →2,4)-α-d-glucopyranose-(1→ and →2)-β-d-mannopyranose-(1→ and two terminal glucopyranose branches. Biochemical analysis from mammalian animal experiments demonstrated that SHP-1 possesses the ability to enhance antioxidant enzyme activities, such as catalase (CAT) and superoxide dismutase (SOD) activities, Trolox equivalent antioxidant capacity (TEAC) in serum of d-galactose-aged mice, while reducing lipofuscin levels, another indicator of cell aging, indicating a potential association with anti-aging activities in a dose dependent manner. This compound had a favourable influence on immune organ indices, and a marked amelioration ability of histopathological hepatic lesions such as necrosis, karyolysis and reduced inflammation and apoptosis in mouse hepatocytes. These results suggest that SHP-1 has strong antioxidant activities and a significant protective effect against oxidative stress or hepatotoxicity induced by d-galactose in mice and it could be developed as a food ingredient or a pharmaceutical to prevent many age-associated diseases such as major depressive disorder and hepatotoxicity. To our knowledge, this is the first report on the antioxidant effects of a novel purified exopolysaccharide derived from Phellinus sp. © 2016 The Royal Society of Chemistry.spa
dc.format.extent12 páginasspa
dc.format.mediumDigitalspa
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1039/C6FO00422A
dc.identifier.instnameinstname:Universidad Icesi
dc.identifier.issn2042-6496
dc.identifier.otherhttp://xlink.rsc.org/?DOI=C6FO00422A
dc.identifier.reponamereponame:Biblioteca Digital
dc.identifier.repourlrepourl:https://repository.icesi.edu.co/
dc.identifier.urihttp://hdl.handle.net/10906/82416
dc.language.isoengeng
dc.publisherRoyal Society of Chemistry
dc.publisher.departmentDepartamento de Ingeniería Industrialspa
dc.publisher.facultyFacultad de Ingenieríaspa
dc.publisher.placeCambridge
dc.publisher.programIngeniería Industrialspa
dc.relation.citationendpage3479
dc.relation.citationstartpage3468
dc.relation.ispartofFood and Function, Vol. 7, No. 8 - 2016
dc.rightsEL AUTOR, expresa que la obra objeto de la presente autorización es original y la elaboró sin quebrantar ni suplantar los derechos de autor de terceros, y de tal forma, la obra es de su exclusiva autoría y tiene la titularidad sobre éste. PARÁGRAFO: en caso de queja o acción por parte de un tercero referente a los derechos de autor sobre el artículo, folleto o libro en cuestión, EL AUTOR, asumirá la responsabilidad total, y saldrá en defensa de los derechos aquí autorizados; para todos los efectos, la Universidad Icesi actúa como un tercero de buena fe. Esta autorización, permite a la Universidad Icesi, de forma indefinida, para que en los términos establecidos en la Ley 23 de 1982, la Ley 44 de 1993, leyes y jurisprudencia vigente al respecto, haga publicación de este con fines educativos Todo persona que consulte ya sea la biblioteca o en medio electrónico podrá copiar apartes del texto citando siempre la fuentes, es decir el título del trabajo y el autor.spa
dc.rights.accessrightsinfo:eu-repo/semantics/openAccesseng
dc.rights.coarhttp://purl.org/coar/access_right/c_abf2
dc.rights.licenseAtribución-NoComercial-SinDerivadas 4.0 Internacional (CC BY-NC-ND 4.0)
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.proposalAlimentos - Análisisspa
dc.subject.proposalNutriciónspa
dc.subject.proposalAntioxidantesspa
dc.subject.proposalAnálisis bioquímicospa
dc.subject.proposalEnzimasspa
dc.subject.proposalIngeniería de producciónspa
dc.subject.proposalProduction engineeringeng
dc.titleStructural characterization and anti-aging activity of a novel extracellular polysaccharide from fungus Phellinus sp. in a mammalian system
dc.type.coarhttp://purl.org/coar/resource_type/c_2df8fbb1
dc.type.coarversionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.driverinfo:eu-repo/semantics/articleeng
dc.type.localArtículospa
dc.type.versioninfo:eu-repo/semantics/publishedVersioneng

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