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Ítem Persistently high venous-to-arterial carbon dioxide differences during early resuscitation are associated with poor outcomes in septic shock(BioMed Central, 2013-12-01) Arango Dávila, César AugustoVenous-to-arterial carbon dioxide difference (Pv-aCO2) may reflect the adequacy of blood flow during shock states. We sought to test whether the development of Pv-aCO2 during the very early phases of resuscitation is related to multi-organ dysfunction and outcomes in a population of septic shock patients resuscitated targeting the usual oxygen-derived and hemodynamic parameters.
Ítem Effects of fluids on microvascular perfusion in patients with severe sepsis(Springer-Verlag, 2010-06-01) Donadello, KatiaPurpose To evaluate the effects of fluid administration on microcirculatory alterations in sepsis. Methods With a Sidestream Dark Field device, we evaluated the effects of fluids on the sublingual microcirculation in 60 patients with severe sepsis. These patients were investigated either within 24 h (early, n = 37) or more than 48 h (late, n = 23) after a diagnosis of severe sepsis. Hemodynamic and microcirculatory measurements were obtained before and 30 min after administration of 1,000 ml Ringer’s lactate (n = 29) or 400 ml 4% albumin (n = 31) solutions.Ítem Epidemiology and clinical outcomes of octogenarian patients in an intensive care unit from a developing country(Springer, 2010-09-01) Ospina Tascón, Gustavo AdolfoAround the world, the elderly population is growing faster than the total population, and this difference in growth rates is increasing [1]. In 1950, 1 in every 20 individuals was aged 65 years or older; by the year 2050, this figure is projected to increase to nearly 1 in 6 (Fig. 1) [1]. These population trends represent a looming crisis for healthcare systems around the world, and understanding patterns of care and outcomes for the ageing segment of the population is vital when planning for future healthcare needs in all countries.Ítem Factors predicting re-laparotomy in severe secondary peritonitis(Springer Netherlands, 2010-01-01) Ospina Tascón, Gustavo AdolfoArtículo del doctor Gustavo Adolfo Ospina Tascón, Internista, Intensivista con PhD en Ciencias Biomedicas que ejerce en la Fundación Valle del Lili y profesor de la Universidad Icesi, es uno de los autores del estudio Andromeda Shock, expuesto en la Sesión Hot Topics del Congreso de la Sociedad Europea de Cuidados Intensivos, donde se destacan y se dan a conocer los trabajos mas importantes en el campo de la medicina de cuidados intensivos en el mundo. Entre ellos la estrategia de reanimación en diferentes momentos. Específicamente en el estudio en mención, el médico cirujano Ospina utilizando la técnica de Laparotomia Exploratoria que se practica en el paciente bajo anestesia general, con una incisión en el abdomen examina los órganos en procura de diagnosticar la Peritonitis secundaria severa.Ítem Intermediate Care Units Should Be “Step Down Units” In Septic Patients(Springer, 2010-09-01) Ospina Tascón, Gustavo Adolfo[No contiene resumen]Ítem Persistence of high venous-to-arterial carbon dioxide difference during early goal-directed therapy could be related to multiorgan dysfunction in septic(Springer, 2010-09-01) Ospina Tascón, Gustavo AdolfoVenous-to-arterial carbon dioxide difference (Pv-aCO2) may reflect the adequacy of blood flow during shock states. We sought to test whether the development of Pv-aCO2 during the very early phases of resuscitation is related to multi-organ dysfunction and outcomes in a population of septic shock patients resuscitated targeting the usual oxygen-derived and hemodynamic parameters.Ítem The persistence of microvascular dysfunction is associated with a worse outcome in patients with severe sepsis(Springer, 2010-09-01) Neves, Ana P.The persistence of microvascular dysfunction is associated with a worse outcome in patients with severe sepsis. Elaborado por Gustavo Adolfo Ospina,Jacques Creteur, Ana P. Neves, Daniel De Backer, Jean Luis Vincent, publicado por SppringerÍtem Venous-Arterial Co2 To Arterial-Venous 02 Content Difference Ratio Combined With Lactate Levels As A Marker Of Resustation In Septic Shock(Springer, 2013-10-01) Granados Sánchez, Mariana[No contiene resumen]Ítem Microcirculatory alterations are associated with pulmonary dead-space fraction in moderate and severe ards(Springer International Publishing, 2015-10-03) Madriñán, HJShunt-induced hypoxemia i s considered the primary pathophysiological abnormality and main diagnostic cri- teria of acute respiratory distress syndrome (ARDS). However, increases in dead- space ventilation (VD/VT) can also contribute to gas exchange alterations in ARDS. Systemic microcirculatory alterations described during inflammatory conditions are characterized by perfusion heterogeneity and theoretically pulmonary microcirculatory heterogene ity could lead to imbalance pulmonary ventilation/perfusion relationship. Thus, we hypothesized that systemic microvascular alterations could reflect increased VD/VT in ARDS.Ítem Monitoring the microcirculation in the critically ill patient: current methods and future approaches(Springer, 2010-11-01) De Backer, DanielTo discuss the techniques currently available to evaluate the microcirculation in critically ill patients. In addition, the most clinically relevant microcirculatory alterations will be discussed. Review of the literature on methods used to evaluate the microcirculation in humans and on microcirculatory alterations in critically ill patients. In experimental conditions, shock states have been shown to be associated with a decrease in perfused capillary density and an increase in the heterogeneity of microcirculatory perfusion, with non-perfused capillaries in close vicinity to perfused capillaries. Techniques used to evaluate the microcirculation in humans should take into account the heterogeneity of microvascular perfusion. Microvideoscopic techniques, such as orthogonal polarization spectral (OPS) and sidestream dark field (SDF) imaging, directly evaluate microvascular networks covered by a thin epithelium, such as the sublingual microcirculation. Laser Doppler and tissue O(2) measurements satisfactorily detect global decreases in tissue perfusion but not heterogeneity of microvascular perfusion. These techniques, and in particular laser Doppler and near-infrared spectroscopy, may help to evaluate the dynamic response of the microcirculation to a stress test. In patients with severe sepsis and septic shock, the microcirculation is characterized by a decrease in capillary density and in the proportion of perfused capillaries, together with a blunted response to a vascular occlusion test.