Logo_Icesi

Filtros

2016 - 20172
Restablecer filtros

Ajustes

Autor: Salamanca Mejía, Constaín HugoTema: Métodos de investigación en bioquímica

Resultados de la búsqueda

Mostrando 1 - 2 de 2
  • No hay miniatura disponible
    Ítem
    Physicochemical characterization of in situ drug-polymer nanocomplex formed between zwitterionic drug and ionomeric material in aqueous solution
    (Elsevier, 2017-03-01) Villada, Juan D.
    Biocompatible polymeric materials with the potential to form functional structures, in association with different therapeutic molecules, in physiological media, represent a great potential for biological and pharmaceutical applications. Therefore, here the formation of a nano-complex between a synthetic cationic polymer and model drug (ampicillin trihydrate) was studied. The formed complex was characterized by size and zeta potential measurements, using dynamic light scattering and capillary electrophoresis. Moreover, the chemical and thermodynamically stability of these complexes were studied. The ionomeric material, here referred as EuCl, was obtained by equimolar reaction between Eudragit E and HCl. The structural characterization was carried out by potentiometric titration, FTIR spectroscopy, and DSC. The effect of pH, time, polymer concentration and ampicillin/polymer molar ratio over the hydrodynamic diameter and zeta potential were established
  • No hay miniatura disponible
    Ítem
    Relationship between surface properties and in vitro drug release from a compressed matrix containing an amphiphilic polymer materia.
    (Multidisciplinary Digital Publishing Institute (MDPI), 2016-06-24) Pineda, Diego; Corre, Clara E.; Yarce, Cristhian J.; Salamanca Mejía, Constaín Hugo
    The performance of compressed tablet drug delivery systems made using polymeric materials depend on multiple factors, such as surface properties like contact angle, surface free energy and water absorption rate, besides the release mechanisms driven by the kind of polymer used. Hence, it should be possible to establish a relationship between the surface properties and the drug release kinetics. Compressed tablets with different proportions of poly(maleic acid-alt-octadecene) potassium salt (0%, 10%, 20%, 30% and 40%) were prepared. Blends of a model drug (ampicillin trihydrate) and the polymer material were analyzed by DSC.