Título : | Structural characterization and anti-aging activity of a novel extracellular polysaccharide from fungus Phellinus sp. in a mammalian system |
Autor : | Peterson, Eric Charles Dun, Ying Guo, Dan dan Li, Dan yang Ma, Xiao-kui |
Fecha de publicación : | 1-ago-2016 |
Editorial : | Royal Society of Chemistry |
Palabras clave : | Alimentos - Análisis Nutrición Antioxidantes Análisis bioquímico Enzimas Ingeniería de producción Production engineering |
Resumen : | Little is known about the chemical structure of purified extracellular polysaccharides from Phellinus sp., a fungal species with known medicinal properties. A combination of IR spectroscopy, methylation analysis and NMR were performed for the structural analysis of a purified extracellular polysaccharide derived from Phellinus sp. culture, denoted as SHP-1, along with an evaluation of the anti-aging effect in vivo of the polysaccharide supplementation. The structure of SHP-1 was established, with a backbone composed of →2,4)-α-d-glucopyranose-(1→ and →2)-β-d-mannopyranose-(1→ and two terminal glucopyranose branches. Biochemical analysis from mammalian animal experiments demonstrated that SHP-1 possesses the ability to enhance antioxidant enzyme activities, such as catalase (CAT) and superoxide dismutase (SOD) activities, Trolox equivalent antioxidant capacity (TEAC) in serum of d-galactose-aged mice, while reducing lipofuscin levels, another indicator of cell aging, indicating a potential association with anti-aging activities in a dose dependent manner. This compound had a favourable influence on immune organ indices, and a marked amelioration ability of histopathological hepatic lesions such as necrosis, karyolysis and reduced inflammation and apoptosis in mouse hepatocytes. These results suggest that SHP-1 has strong antioxidant activities and a significant protective effect against oxidative stress or hepatotoxicity induced by d-galactose in mice and it could be developed as a food ingredient or a pharmaceutical to prevent many age-associated diseases such as major depressive disorder and hepatotoxicity. To our knowledge, this is the first report on the antioxidant effects of a novel purified exopolysaccharide derived from Phellinus sp. © 2016 The Royal Society of Chemistry. |
URI : | http://repository.icesi.edu.co/biblioteca_digital/handle/10906/82416 |
ISSN : | 2042-6496 |
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DOI : | https://doi.org/10.1039/C6FO00422A |
Aparece en las colecciones: | Nuevo conocimiento - ICUBO
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