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Ítem Persistently high venous-to-arterial carbon dioxide differences during early resuscitation are associated with poor outcomes in septic shock(BioMed Central, 2013-12-01) Arango Dávila, César AugustoVenous-to-arterial carbon dioxide difference (Pv-aCO2) may reflect the adequacy of blood flow during shock states. We sought to test whether the development of Pv-aCO2 during the very early phases of resuscitation is related to multi-organ dysfunction and outcomes in a population of septic shock patients resuscitated targeting the usual oxygen-derived and hemodynamic parameters.Ítem Can venous-to-arterial carbon dioxide differences reflect microcirculatory alterations in patients with septic shock?(Springer Verlag, 2016-02-01) Ospina Tascón, Gustavo AdolfoPurpose Septic shock has been associated with microvascular alterations and these in turn with the development of organ dysfunction. Despite advances in video microscopic techniques, evaluation of microcirculation at the bedside is still limited. Venous-to-arterial carbon dioxide difference (Pv-aCO2) may be increased even when venous O2 saturation (SvO2) and cardiac output look normal, which could suggests microvascular derangements. We sought to evaluate whether Pv-aCO2 can reflect the adequacy of microvascular perfusion during the early stages of resuscitation of septic shock.