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Ítem B lymphocytes: development, tolerance, and their role in autoimmunity-focus on systemic lupus erythematosus.(Elsevier, 2013-01-01) Cañas Dávila, Carlos AlbertoB lymphocytes are the effectors of humoral immunity, providing defense against pathogens through different functions including antibody production. B cells constitute approximately 15% of peripheral blood leukocytes and arise from hemopoietic stem cells in the bone marrow. It is here that their antigen receptors (surface immunoglobulin) are assembled. In the context of autoimmune diseases defined by B and/or T cell autoreactive that upon activation lead to chronic tissue inflammation and often irreversible structural and functional damage, B lymphocytes play an essential role by not only producing autoantibodies but also functioning as antigen-presenting cells (APC) and as a source of cytokines. In this paper, we describe B lymphocyte functions in autoimmunity and autoimmune diseases with a special focus on their abnormalities in systemic lupus erythematosus.Ítem Drug-induced lupus in anti-TNF-alpha therapy and its treatment with rituximab(Springer Heidelberg, 2012-10-01) Vallejo, SantiagoWe report three patients with rheumatoid arthritis (RA) who were treated with anti-TNF-α agents and who developed drug-induced lupus (DIL). Two of them received etanercept and the remainder adalimumab. We also present the favorable response observed with the withdrawal of the anti-TNF-alpha agents and the introduction of rituximab. Through this intervention, we observed a very good control of the activity of both DIL and RA without additional adverse reactions.Ítem Historia del lupus y embarazo(Ediciones Universidad Tecnologica de Boliva, 2011-01-01) Toro, CarlosRealizar análisis periódicos de la información contenida en el registro. Determinar la frecuencia de las diferentes enfermedades autoinmunes diagnosticadas, manejadas y seguidas en la FVL