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Ítem Enfermedades autoinmunes(Fundación Valle del Lili, 2008-08-01) Tobón, Gabriel Jaime; Fundación Valle de Lili¿Qué es el sistema inmunológico?/¿Qué es la autoinmundad?/ ¿Qué tan frecuentes son las enfermedades autoinmunes?/¿Cuáles son las enfermedades autoinmunes?/¿Cómo se tratan las enfermedades autoinmunes?/Enfermedades autoinmunes más comunes.Ítem Síndrome seco(Fundación Valle del Lili, 2013-04-01) Muñoz, EvelynSe conoce como SÍNDROME SECO al conjunto de manifestaciones clínicas relacionadas con la sensación de sequedad ocular y sequedad bucal denomidas en medicina como keratoconjuntivis sica y xerostomia, respectivamente. SÍNDROME SECO es un problema común, a tal punto que alrededor de 3.23 millones de mujeres y 1.68 millones de hombres de mas de 50 años en los Estados Unidos padecen de ojo seco, y decenas de millones pueden tener síntomas menos serveros dependientes de condiciones adversas del mido, como la contaminación ambiental. Así mismo la boca seca, que antes se cría exclusiva de los pacientes de la tercera edad, se ha demostrado que puede afectar entre el 20% y 40% de la población general. Ambas manifestaciones pueden presentarse en conjunto o de forma individual según la causa desencadenante.
Ítem Pneumocystis jirovecii pneumonia in two patients with systemic lupus erythematosus after rituximab therapy(Springer-Verlag London Ltd, 2014-03-01) Betancurt, J. F.New cases of Pneumocystis jirovecii pneumonia (PJP) have recently been reported in patients with systemic lupus erythematosus (SLE) after rituximab therapy. Several factors may contribute to susceptibility to P. jirovecii infection in this type of patients, including the immunological characteristics of the disease, the mechanisms of rituximab action, environmental factors, and the biological characteristics of the fungus. We report two patients with SLE who developed PJP after rituximab therapy.Ítem The importance of evolution in the development and course of rheumatoid arthritis(Elsevier, 2014-06-01) Cañas Dávila, Carlos AlbertoRheumatoid arthritis (RA) is a complex autoimmune disease of recent evolutionary origin. Genetic drift determines diverse polymorphisms implicated in the susceptibility to RA including the major histocompatibility complex (MHC) class II genes in the so-called shared epitope. These genes originated after the divergence between Homo and Pan from their common ancestry Ardipithecus ramidus about 5 million years ago. Natural selection determined the particular changes in the legs (bipedal position), hands, neck, brain and eusociality in humans which influence the clinical presentation of RA. In this article, we hypothesized that the origin and course of RA may be explainable in the light of evolution.Ítem Recovery of severe muscular and fascial calcinosis after treatment with bisphosphonates in a child with juvenile dermatomyositis(Lippincott Williams and Wilkins, 2015-08-01) Bonilla Abadía, FabioAbstract: Juvenile dermatomyositis (JDM) is a serious systemic autoimmune condition primarily affecting proximal muscles and skin, which is frequently associated with calcinosis. We report a case of a 10-year-old boy with JDM and severe calcification deposits along fasciae and muscle planes. He complained of symptoms associated to JDM with pulmonary involvement since 1 year before receiving medical attention. Three months before consultation, he experienced bilateral leg pain accompanied by progressive hardening of muscles and the presence of small nodules around the elbows and submandibular region. Computed tomography images revealed a severe “eggshell” calcification pattern of the lower-limb muscular fasciae. Significant clinical and radiological improvement was achieved after 30 months of alendronate therapy