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Ítem Resistencia a fármacos antituberculosis en pacientes coinfectados con tuberculosis y virus de la inmunodeficiencia humana, en un hospital de referencia de 2007 a 2010 en Cali (Colombia)(Asociación Colombiana de Infectología, 2012-09-01) Rosso Suárez, FernandoLa resistencia a los fármacos antituberculosis es de gran interés en salud pública. La coinfección con virus de la inmunodeficiencia humana (VIH) ha cambiado el comportamiento de dicha enfermedad. El objetivo de nuestro estudio es determinar la prevalencia de la resis- tencia a fármacos antituberculosis en pacientes coinfectados con tuberculosis (TB)/VIH. Método: Se realizó un estudio retrospectivo a partir de la revisión de los registros clínicos de casos nuevos y fracasos de TB coinfectados con VIH que consultaron a un centro de atención de nivel IV desde 2007 a 2010 y que contaban con pruebas de susceptibilidad. Resultados: Un 52% de los pacientes procedían de Santiago de Cali, y un 8%, de Buenaven- tura. La TB se presentó de forma extrapulmonar en el 80% de los pacientes. Del 48% de los sujetos que conocían su estado VIH previo al diagnóstico de la TB, el 40% estaban en terapia antirretroviral. El 16% de los casos eran fracasos, entre los cuales se detectó un caso multi- drogorresistente. De los casos nuevos, se encontró monorresistencia a la isoniazida del 14%, y una resistencia total del 28%.
Ítem Catastrophic Antiphospholipid Syndrome Triggered by Fulminant Chikungunya Infection in a Patient with Systemic Lupus Erythematosus(John Wiley and Sons Inc., 2016-03-28) Betancur, Juan FelipeThe patient, a 21-year-old woman, was admitted to the intensive care unit with a 4-day history of fever, arthritis of the hands and feet, oli- guria with anasarca, diarrhea, and widespread skin rash. Systemic lupus erythematosus had been diagnosed 5 years previously. She was positive for lupus anticoagulant and anticardiolipin antibody but had no history of thrombotic or obstetric manifestations. Laboratory tests for infection and immunologic or biochemical abnormalities were performed and, based on multiple abnormal findings, treatment with broad-spectrum antibiotics was instituted.Ítem Curso clínico de pacientes de trasplante autógeno de médula ósea portadores del virus linfotrópico humano(Elsevier Doyma, 2015-07-01) Vélez, Juan DiegoHuman T-lymphotropic virus 1 infection is common in Colombia's Pacific coast and has been linked to adult T-cell leukemia/lymphoma and human T-lymphotropic virus 1-associated myelopathy in a low percentage of cases. In patients with solid organ transplantation, these diseases occur more quickly than in other scenarios but in bone marrow transplantation the true impact is unknown. We describe 3 seropositive patients with lymphoma who underwent autologous stem cell transplantation; in one case there was relapse of the hematologic malignancy and death occurred as a result. Another patient had symptoms compatible with human T-lymphotropic virus 1-associated myelopathy and the last patient had a graft vs. host disease. In seropositive people who need hematopoietic cell transplantation, an active search for this virus is required to be able to follow and assess the virus's impact on outcomes, as well as to assess whether the evolution could change according to the transplant conditioning regimen.