Caracterización de las dispersiones acuosas homogéneas de hidroxipropilmetil celulosa rh y alginato de sodio, empleadas como aglutinantes en la fabricación de productos farmacéuticos granulados de uso veterinario.

This document represent a research to the aqueous dispersions of two binders at different concentrations, Hydroxypropylmethyl Cellulose RH (3 %, 4 %, 5 %, 6 % and 7 % w/v) and Sodium alginate (0.5 %, 1 %, 2 % , 3 % and 4 % w/v), in these were determinated physicochemical characteristics as pH, density (specific weight) and viscosity, which were reported in their respective datasheets. As well also, establish the performance characteristics of the granulation, through fluidization technique for three of the five concentrations studied of the aqueous dispersions of each material. The functionality characteristics or performance about the proposed use as binders corresponded to granulometric measurements and the fluidity; this determinations were made to the product obtained of granulation process of a diluent commonly used, Lactose monohydrate alimentary-grade, with each of the selected binder dispersions in a granulator of fluid bed. Actually, the Pharmaceutical Laboratory Carval Colombia, company dedicated to the production and marketing of veterinary pharmaceuticals, is interested in the development and production of dosage forms types granulated, which bring on the uniform distribution of the product in the mixing of products where they are incorporated, ensuring correct dosing of the product, since this prevent the segregation of the active ingredient, improve the homogeneity of the mixing process, and allow to obtain a product with good flow and a lower percentage of fine dusts. All this proof the need of have useful information about the possible use of different excipients in a pharmaceutical shape of granulate type, remain central the binders.