Evaluación de bases orgánicas para la síntesis de ácido cannabidiólico a partir de cannabidiol
| dc.audience | Todo Público | |
| dc.contributor.advisor | Pérez Muñoz, Ruby Lizeth | |
| dc.contributor.advisor | Enríquez Valencia, Diego Javier | |
| dc.contributor.author | Silva Mafla, Julian Andrés | |
| dc.coverage.spatial | Cali de Lat: 03 24 00 N degrees minutes Lat: 3.4000 decimal degrees Long: 076 30 00 W degrees minutes Long: -76.5000 decimal degrees. | |
| dc.date.accessioned | 2025-06-13T20:40:39Z | |
| dc.date.available | 2025-06-13T20:40:39Z | |
| dc.date.issued | 2024-12-12 | |
| dc.description.abstract | In this research project, the effect of different organic bases and cocatalysts on the synthesis of cannabidiolic acid (CBDA) from cannabidiol (CBD) was evaluated, with the aim of optimizing the reaction yield. The bases used, such as (1,8-diazabicyclo[5.4.0]undec-7-ene (DBU), potassium t-butoxide (t-BuOK), and an inorganic base such as sodium hydride (NaH), along with metals such as magnesium, zinc, and nickel, achieved yields between 7.3% and 2.5%. Although these results did not significantly surpass those reported in previous studies, the need arises to optimize the process. | eng |
| dc.description.abstract | En este proyecto de investigación, se evaluó el efecto de diferentes bases orgánicas y cocatalizadores en la síntesis de ácido cannabidiólico (CBDA) a partir de cannabidiol (CBD), con el objetivo de optimizar el rendimiento de la reacción. Las bases empleadas como el (1,8- diazabicyclo[5.4.0]undec-7-eno (DBU), t-butóxido de potasio (t-BuOK) y una base inorgánica como el hidruro de sodio (NaH) junto con metales como magnesio, zinc y níquel lograron rendimientos entre 7.3% y 2.5%. Aunque estos resultados no superaron significativamente los reportados en estudios previos, surge la necesidad de optimizar el proceso. | spa |
| dc.description.degreelevel | Profesional | |
| dc.description.degreename | Trabajo de Grado para obtener el título del Programa de Química Farmacéutica | |
| dc.description.tableofcontents | Resumen -- Introducción -- Metodología -- Resultados y discusión -- Conclusiones -- Agradecimientos -- Referencias bibliográficas -- Anexos | spa |
| dc.format.extent | 21 páginas | |
| dc.format.medium | Digital | |
| dc.format.mimetype | application/pdf | |
| dc.identifier.OLIB | https://biblioteca2.icesi.edu.co/cgi-olib/?oid=365038 | |
| dc.identifier.instname | instname:Universidad Icesi | |
| dc.identifier.reponame | reponame:Biblioteca Digital | |
| dc.identifier.repourl | repourl:https://repository.icesi.edu.co/ | |
| dc.identifier.uri | https://hdl.handle.net/10906/130364 | |
| dc.language.iso | spa | |
| dc.publisher | Universidad Icesi | |
| dc.publisher.faculty | Barberi de Ingeniería, Diseño y Ciencias Aplicadas | |
| dc.publisher.place | Santiago de cali | |
| dc.publisher.program | Química Farmacéutica | |
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| dc.rights | EL AUTOR, expresa que la obra objeto de la presente autorización es original y la elaboró sin quebrantar ni suplantar los derechos de autor de terceros, y de tal forma, la obra es de su exclusiva autoría y tiene la titularidad sobre éste. PARÁGRAFO: en caso de queja o acción por parte de un tercero referente a los derechos de autor sobre el artículo, folleto o libro en cuestión, EL AUTOR, asumirá la responsabilidad total, y saldrá en defensa de los derechos aquí autorizados; para todos los efectos, la Universidad Icesi actúa como un tercero de buena fe. Esta autorización, permite a la Universidad Icesi, de forma indefinida, para que en los términos establecidos en la Ley 23 de 1982, la Ley 44 de 1993, leyes y jurisprudencia vigente al respecto, haga publicación de este con fines educativos Todo persona que consulte ya sea la biblioteca o en medio electróico podrá copiar apartes del texto citando siempre la fuentes, es decir el título del trabajo y el auto | spa |
| dc.rights.accessrights | info:eu-repo/semantics/openAccess | |
| dc.rights.coar | http://purl.org/coar/access_right/c_abf2 | |
| dc.rights.license | Attribution-NonCommercial-NoDerivatives 4.0 International | en |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | |
| dc.subject.proposal | Acido cannabidiólico (CBDA) | spa |
| dc.subject.proposal | Carboxilación | spa |
| dc.subject.proposal | Dióxido de carbono | spa |
| dc.subject.proposal | Dbu | spa |
| dc.subject.proposal | Cannabidiolic acid (CBDA) | eng |
| dc.subject.proposal | Carboxylation | eng |
| dc.subject.proposal | Carbon dioxide | eng |
| dc.subject.proposal | Dbu | eng |
| dc.subject.proposal | Trabajo de grado de Química Farmacéutica | spa |
| dc.title | Evaluación de bases orgánicas para la síntesis de ácido cannabidiólico a partir de cannabidiol | spa |
| dc.type | bachelor thesis | |
| dc.type.coar | http://purl.org/coar/resource_type/c_7a1f | |
| dc.type.coarversion | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |
| dc.type.driver | info:eu-repo/semantics/bachelorThesis | |
| dc.type.local | Trabajo de grado | |
| dc.type.version | info:eu-repo/semantics/publishedVersion |
