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Ítem Amyloid-beta immunotherapy: the hope for Alzheimer disease?(Universidad del Valle, 2016-10-01) Lopera, FranciscoAlzheimer disease (AD) is the most prevalent form of dementia of adult-onset, characterized by progressive impairment in cognition and memory. There is no cure for the disease and the current treatments are only symptomatic. Drug discovery is an expensive and time-consuming process; in the last decade no new drugs have been found for AD despite the efforts of the scientific community and pharmaceutical companies. The Aβ immunotherapy is one of the most promising approaches to modify the course of AD. This therapeutic strategy uses synthetic peptides or monoclonal antibodies (mAb) to decrease the Aβ load in the brain and slow the progression of the disease. Therefore, this article will discuss the main aspects of AD neuropathogenesis, the classical pharmacologic treatment, as well as the active and passive immunization describing drug prototypes evaluated in different clinical trials.Ítem T-Cell-Based Immunosuppressive Therapy Inhibits the Development of Natural Antibodies in Infant Baboons(2012-04-27) Echeverri Junca, Gabriel JaimeBackground. We set out to determine whether B-cell tolerance to A/B-incompatible alloantigens and pig xenoantigens could be achieved in infant baboons. Methods. Artery patch grafts were implanted in the abdominal aorta in 3-month-old baboons using A/B-incompatible (AB-I) allografts or wild-type pig xenografts (pig). Group 1 (Gp1) (controls, n=6) received no immunosuppressive therapy (IS) and no graft. Gp2 (n=2) received an AB-I or pig graft but no IS. Gp3 received AB-I grafts+IS (Gp3A: n=2) or pig grafts+IS (Gp3B: n=2). IS consisted of ATG, anti-CD154mAb, and mycophenolate mofetil until age 8 to 12 months. Gp4 (n=2) received IS only but no graft. Results. In Gp1, anti-A/B and cytotoxic anti-pig immunoglobulin-M increased steadily during the first year. Gp2 became sensitized to donor-specific AB-I or pig antigens within 2 weeks. Gp3 and Gp4 infants that received anti-CD154mAb made no or minimal anti-A/B and anti-pig antibodies while receiving IS.Ítem Costimulation blockade in pig artery patch xenotransplantation - a simple model to monitor the adaptive immune response in nonhuman primates.(Wiley, 2012-07-01) Echeverri Junca, Gabriel JaimeBACKGROUND: CD154 blockade-based immunosuppression successfully prevents both humoral and cellular adaptive immune responses in baboons receiving α1,3-galactosyltransferase gene-knockout (GTKO) pig organs. Using a GTKO pig artery transplantation model in baboons, we evaluated the efficacy of CD28/B7 costimulatory pathway blockade in comparison with CD154 blockade.Ítem Arte y síndrome de Down(Pontificia Universidad Javeriana, 2011-10-01) Pachajoa Londoño, Harry MauricioEl síndrome de Down es la alteración cromosómica más frecuente y se presenta en 1 de cada 700 nacimientos vivos, es la primera causa de retardo mental de origen genético, caracterizado por retardo mental y características físicas típicas como braquicefalia, occipucio plano, fisuras palpebrales inclinadas hacia arriba, pliegues epicanticos y orejas de implantación baja entre otras, causadas por una copia extra del cromosoma
Ítem Rapid, severe neurological impairmentassociated with paraneoplastic cerebellardegeneration and anti-Yo antibodies(Elsevier, 2014-03-01) Ariza Araujo, Yoseth Jesualdo12The patient was a 69-year-old woman treated at ourhospital for left gaze deviation, generalised hypotonia fol-lowed by limb hypertonia, and loss of consciousness lastingapproximately 5 minutes. Medical history included arterialhypertension and hypothyroidism, both of which were con-trolled.Ítem Early Islet Damage After Direct Exposure of Pig Islets to Blood:Has Humoral Immunity Been Underestimated?(Cognizant Communication Corporation, 2012-08-01) Ekser, BurcinCurrently, islet transplantation as a cell therapeutic option for type 1 diabetes occurs via islet injection into the portal vein. Direct contact between islets and blood is a pathophysiological “provocation” that results in the instant blood-mediated inflammatory reaction (IBMIR) and is associated with early islet loss. However, the nature of the various insults on the islets in the blood stream remains mostly unknown. To gain insight into the mechanisms, we utilized a simplified in vitro model in which islets were exposed to blood in different clinically relevant but increasingly challenging, autologous, allogeneic, and xenogeneic combinations. Irrespective of the blood type and species compatibility, islets triggered blood clottingÍtem Terapia con anticuerpos monoclonales en Cardiología y Medicina Interna(Sociedad Colombiana de Cardiologia, 2016-07-12) Adams Sánchez, Christian DavidThe monoclonal antibodies (mAb) constitute a new therapeutic tool in cardiovascular medicine, based in the development of the molecular biology in this area. The understanding of therapeutic principles, types and mechanism of action of these drugs is essential for proper use and management of adverse reactions. We discuss the profile of the PCSK-9 inhibitors, the Dabigatran antidote, the abciximab, the digoxin antidote, the therapy in heart transplantation, and a possible cardiovascular use of monoclonal antibodies used in rheumatology.Ítem Seroprevalence of human T-lymphotropic virus in blood bank donors at Fundación Valle del Lili, Cali, Colombia, 2008-2014(Instituto Nacional de Salud, 2016-01-01) Macía, CarmenzaEl virus linfotrópico humano (HTLV) de tipos I y II es un retrovirus prevalente en la Costa Pacífica colombiana que puede transmitirse por transfusiones de sangre. En el 2014 se reglamentó la tamización para bancos de sangre con el fin de reducir la transmisión por medio de la donación. La información sobre la seroprevalencia del virus en el suroccidente colombiano es limitada. Objetivo. Determinar la seroprevalencia, el comportamiento a lo largo del tiempo de los resultados reactivos antes y después de la introducción del inmunoensayo Western blot y la concomitancia del HTLV con otros marcadores de infección en donantes de un banco de sangre de Cali, Colombia.