Apropiación social del conocimiento - BIO

URI permanente para esta colecciónhttp://hdl.handle.net/10906/78216

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A reliability assessment software using Kinect to complement the clinical evaluation of Parkinson's disease
(Institute of Electrical and Electronics Engineers Inc., 2015-11-04) Arango Paredes, Juan david
Parkinson's disease is characterized by alterations in the gait pattern that may increase the risk of falls. Variations in the gait pattern cannot be objectively measured in clinical examination, so it is necessary to adapt devices to measure objectively, valid and replicable changes in gait patterns that are part of the evolution of the disease and / or pharmacotherapy. In an interdisciplinary effort, we developed the 'e-Motion Capture System' software, which is able to calculate motor (cadence, stride and step length) and spatiotemporal (velocity and acceleration) parameters that affect quality of life in patients with Parkinson's disease.
Assessment, Monitoring, and Management of Brain-Dead Potential Organ Donors in Europe
(Springer New York, 2013-03-01) Echeverri Junca, Gabriel Jaime
With 34 donors per million population, Spain has impressed the international transplant community with the world's highest rate of organ donation (double the European average), short waiting lists, and reduced reliance on living donation. These data account for the World Health Organization's strategy for extending the so-called Spanish Model across the globe, and for the European Parliament's decision, on May 19, 2010, to incorporate some of the elements of the Spanish Model in its Action Plan on organ donation and transplantation. At present, there are a number of organ transplantation organizations in Europe, though no standardized protocol exists for all countries, and no standardized laws are in place. We describe the most successful model (the Spanish Model for organ donation) and describe in detail the most important recommendations of the 2009 Council of Europe's Guide to Safety and Quality Assurance for the Transplantation of Organs, Tissues and Cells. © 2013 Springer Science+Business Media New York. All rights reserved.
Calcium, channels, intracellular signaling and autoimmunity
(2014-01-01) Cañas Dávila, Carlos Alberto
Calcium (Ca2+) is an important cation able to function as a second messenger in different cells of the immune system, particularly in B and T lymphocytes, macrophages, and mastocytes, among others. Recent discoveries related to the entry of Ca2+ through the store-operated calcium entry (SOCE) have opened a new investigation area about the cell destiny regulated by Ca2+ especially in B and T lymphocytes. SOCE acts through calcium-release-activated calcium (CRAC) channels. The function of CRAC depends upon two recently discovered regulators: the Ca2+ sensor in the endoplasmic reticulum or stromal interaction molecule (STIM-1) and one subunit of CRAC channels called Orai1. This review focuses on the role of Ca2+ signals in B and T lymphocytes functions, the signaling pathways leading to Ca2+ influx, and the relationship between Ca2+ signals and autoimmune diseases.
Comparative evaluation of adhesion formation of prosthetic meshes after intra-abdominal implantation in wistar rats
(IEEE, 2014-07-10) Franco, M. H.
Increasingly biomaterials for the repair of abdominal wall defects are used. The aim of this study was to evaluate adhesion formation of prosthetic meshes after intraabdominal implantation to repair a surgical defect in the anterior abdominal wall. This anatomical defect was repaired by one of the three types of previously sterilized meshes: 1) fibroin 2) fibroin with polyethylene glycol and 3) commercial polypropylene mesh as control. The grip score was significantly higher in the commercial polypropylene mesh. Fibroin is a promising biomaterial for treating defects of the abdominal wall.
Comparative evaluation of adhesion formation of prosthetic meshes after intra-abdominal implantation in wistar rats / Evaluación comparativa de la formación de adherencias de mallas protésicas después de la implantación intraabdominal en ratas
(IEEE, 2012-04-07) Arboleda, A.
Increasingly biomaterials for the repair of abdominal wall defects are used. The aim of this study was to evaluate adhesion formation of prosthetic meshes after intraabdominal implantation to repair a surgical defect in the anterior abdominal wall. This anatomical defect was repaired by one of the three types of previously sterilized meshes: 1) fibroin 2) fibroin with polyethylene glycol and 3) commercial polypropylene mesh as control. The grip score was significantly higher in the commercial polypropylene mesh. Fibroin is a promising biomaterial for treating defects of the abdominal wall. © 2014 IEEE.
Concentración y pureza del ADN de muestras sanguíneas en papel Whatman FTA almacenadas entre 1 a 3 años.
(Universidad del Valle, 2013-01-01) Pachajoa Londoño, Harry Mauricio
El papel Whatman FTA es una alternativa para transportar y almacenar diferentes tipos de muestras y optimizar el tiempo, espacio de almacenamiento y costos. Desde hace varios años se utiliza este método de forma rutinaria y muchos centros médicos almacenan muestras por periodos de tiempo prolongados. Objetivo: Determinar el efecto del tiempo de almacenamiento de muestras de sangre en papel Whatman sobre la concentración del ADN. Materiales y métodos: Se utilizaron 110 muestras de sangre periférica que fueron guardadas en papel filtro durante un periodo de tiempo de uno a tres años. Estas muestras fueron guardadas como parte de programa ECLAMC. La extracción del ADN se realizó por medio de resinas de intercambio iónico (Chelex-100®). Se verificó la amplificación por medio de PCR. Se utilizó el gen GAPDH. Por medio de espectrofotometría utilizando el NanoDrop, se cuantificó cada una de las muestras evaluadas. Resultados: El tiempo de almacenamiento fue diferencial con un rango de 520 a 1135 días. La concentración de ADN presentó variabilidad desde 0.81ng/uL a 5.54ng/ uL. La relación 260/280 osciló desde -5.22 hasta 14.17nm.
Correlación clínica imagenológica en síndrome afásico en un adulto joven: descripción de Caso
(Asociación Colombiana de Neurología, 2013-01-01) Muñoz Ospina, Beatriz
La prevalencia de la enfermedad cerebrovascular en adultos entre 15 y 45 años es del 3 al 5% y las lesiones en la arteria cerebral media (ACM) corresponden al 23%. Entre los factores de riesgo en adultos jóvenes están: dislipidemia (38%), tabaquismo (34%) e hipertensión arterial (20%). El perfil clínico característico del evento isquémico de la ACM puede incluir déficit senso - riomotor y/o trastornos del lenguaje. Puesto que el lenguaje se soporta por redes interconectadas, la tractografía por resonancia magnética permite evaluar los tractos de sustancia blanca implicados en esta función y contribuye en la comprensión del espectro clínico.
Dear Editor
(Universidad del Valle, 2012-01-01) Pachajoa Londoño, Harry Mauricio
Recently, Valencia et al., published a very interesting article called «Lipid profile in a group of patients with Turner's syndrome at Clínica Universitaria Bolivariana in the city of Medellín between 2000 and 2009"1. An article which evaluated lipid levels in patients with Turner syndrome in a Colombian clinic, the study associated results of lipid profile with karyotype and other risk factors for coronary heart disease.
Design and fabrication of a stainless steel base for biomechanical testing of Wistar rat abdominal wall.
(IEEE Computer Society, 2014-01-01) 9th Pan American Health Care Exchanges Conference; Arboleda Carvajal, Alejandro; Franco, Maurizio H.
The mechanical property of materials allows us to know how and how their performance will then be subject to the conditions for which it was designed. The biomechanical properties of biological tissues give an approximation to loads which it may be subjected in its biological environment. The objective of this project was to design a support to allow the biomechanical plunger tests on a sample of tissue from the abdominal wall of Wistar rat. The 1010 stainless steel support was 102 mm diameter and 50 mm of high, and 40 mm diameter extrusion in the middle was attached to the Instron 3366 universal testing machine
Echocardiographic assessment of valve prostheses in the pediatric population
(Sociedad Colombiana de Cardiologia y Cirugia Cardiovascular, 2014-01-01) Santos, Raúl D.
En niños con insuficiencia o estenosis valvular significativa, la intervención de la válvula, ya sea valvuloplastia o reemplazo valvular, suele ser inevitable. El seguimiento de estos pacientes puede ser complejo; los síntomas iniciales de disfunción valvular protésica son inespecíficos y en ocasiones es difícil diferenciar entre los efectos de la disfunción valvular, las patologías no cardíacas, la disfunción ventricular y la hipertensión pulmonar. Aunque el examen físico puede alertar al clínico acerca de alteraciones, se requieren otros métodos diagnósticos para evaluar la función de la prótesis. La ecocardiografía Doppler es el método de elección no invasivo para estudiar la función valvular y pese a que muchas de las mediciones y parámetros de normalidad y anormalidad son extrapolados de estudios en adultos, se han tratado de definir estándares en pacientes pediátricos. Este documento ofrece una revisión acerca de las técnicas usadas en el estudio de las válvulas protésicas con base en literatura científica, consensos internacionales y opiniones de expertos.
Ectrodactyly, ectodermal dysplasia and cleft lip/palate syndrome, report of a case with variable expressivity
(2012-10-01) Pachajoa Londoño, Harry Mauricio
El síndrome ectrodactilia, displasia ectodérmica y fisura de la- bio/paladar es una entidad poco frecuente, asociada a la mu- tación de genes que codifican la proteína p63. Presentamos un caso de un paciente con ectrodactilia en el pie derecho asociada a labio y paladar fisurados, sin otras alteraciones evidentes, con antecedente familiar de labio con paladar fisurado y muerte en el período perinatal. El manejo de cada caso de este síndrome debe ser específico y multidisciplinario.
Effect of Prolonged Strenuous Exercise on Endothelial Function in Non-Elite Runners
(Sociedad Brasileira De Cardiologia, 2010-05-10) Ramírez Escobar, Jorge Hernán
result in an acute depression in endothelial function. However, little is known about the effect of this type of exercise in non-elite runners. Objective: To determine the impact of prolonged strenuous exercise on endothelial function in nonelite runners.
Efficacy of anti-interleukin-6 receptor antibody (tocilizumab) in colombian patients with takayasu’s arteritis
(BMJ Publishing Group Ltd, 2013-06-01) Izquierdo, Jorge H.
Background Takayasu’s arteritis (TA) is a chronic vasculitis that involves aorta and its main branches, where interleukin-6 (IL-6) seems to play a pathogenic role (1,2). The effect in four patients treated with the anti-IL-6 receptor (IL-6R) antibody Tocilizumab was evaluated. Objectives to describe the effect of Tocilizumab in patients of Takayasu’s arteritis. Methods We reviewed the clinical records of 4 patients with TA diagnosed according to current criteria, treated between 2010 and 2011 in a tertiary center in Cali, Colombia. Four patients with a refractory disease to multiple treatments, was began treatment with Tocilizumab at a dose of 8 mg/kg every month in association with metothrexate and/or steroids. Two patients were treated previously with infliximab (IFX) without control of disease. This cases were reported previously (3). Results The cases summaries are as follows: Case 1. A 30 year-old woman with a diagnosis of TA since 2003 presented panaortitis, with involvement of supra-aortic,
Enfermedades neuromusculares : miastenia gravis, enfermedades de la neurona motora y enfermedades del músculo
(Corporación para Investigaciones Biológicas, 2010-01-01) Takeuchi Tan, Yuri
La miasrenia gravis (MG) y las demás enfer· mcdades que afectan la unión ncu romuscular se caracterizan desde el punto de vista clíni· ro y clectrofisiológico por debilidad muscu· lar fluctuante y fatigable, que afectan grupos musculares específicos, se desencadenan o empeoran con la actividad y mejoran con el reposo. La miastenia gravis tiene una preva· lcncia estimada de 43 a 84 casos por millón de habirnntes y la tasa de incidencia anual es de aproximadamente 1 por 300.000
Hereditary multiple exostosis
(2014-01-01) Pachajoa Londoño, Harry Mauricio
Multiple Hereditary Exostoses (HME) is an autossomal dominant disorder that exhibits multiple benign osteocartilaginous bone tumours that arise near the ends of long bones during childhood. The most common complaint is pain and the exostoses may degenerate into chondrosarcomas. We report a female patient who underwent a rehabilitation program to ease her complaints caused by a large exostosis in the left femur and displayed an exostose of the nasal septa, feature never described before in HME. Molecular study confirmed a novel mutation on the EXT 1 gene. The mutation of a cytosine for a guanine nucleotide in the position 830 on the exon 1 of the EXT 1 gene (c.830C > G) caused the replacement of the serine aminoacid for a stop codon in the position 277 of the protein.
Historia del lupus y embarazo
(Ediciones Universidad Tecnologica de Boliva, 2011-01-01) Toro, Carlos
Realizar análisis periódicos de la información contenida en el registro. Determinar la frecuencia de las diferentes enfermedades autoinmunes diagnosticadas, manejadas y seguidas en la FVL
Hyperferritinemic syndrome: Still’s disease and catastrophic antiphospholipid syndrome triggered by fulminant Chikungunya infection: a case report of two patients
(Springer-Verlag London Ltd, 2015-08-02) Echeverry, Alex A.
There are four medical conditions characterized by high levels of ferritin, the macrophage activation syndrome (MAS), adult onset Still’ s disease (AOSD), catastrophic antiphospholipid syndrome (CAPS), and septic shock, that share similar clinical and laboratory features, suggesting a common pathogenic mechanism. This common syndrome entity is termed “the hyperferritinemic syndrome.” Here, we describe two different cases of hyperferritinemic syndrome triggered by Chikungunya fever virus infection: a 21-year-old female with SLE and a 32-year-old male patient who developed AOSD after the coinfection of dengue and Chikungunya viruses.
Intracavitary Irradiation as a Safe Alternative for Cystic Craniopharyngiomas: Case Report and Review of the Literature
(Hindawi Publishing Corporation, 2016-06-05) Lobato-Polo, Javier
Craniopharyngioma treatment remains a challenge for clinicians and patients. There are many treatment alternatives; however one of them (intracavitary irradiation) seeks to control this type of benign brain tumor using minimally invasive techniques, with the specific aim of avoiding causing significant damage to important structures surrounding the sellar/suprasellar region. We present the case of a 3-year-old patient with a predominantly cystic craniopharyngioma who underwent intracavitary irradiation by stereotactic placement. Using this approach, the patient showed a successful response with remission of headaches and hydrocephalus. A reduction in the size of the cyst was achieved, without deterioration of visual fields, with no hormonal supplementation being needed, and with no evidence of focal neurological signs.
Microcirculatory alterations are associated with pulmonary dead-space fraction in moderate and severe ards
(Springer International Publishing, 2015-10-03) Madriñán, HJ
Shunt-induced hypoxemia i s considered the primary pathophysiological abnormality and main diagnostic cri- teria of acute respiratory distress syndrome (ARDS). However, increases in dead- space ventilation (VD/VT) can also contribute to gas exchange alterations in ARDS. Systemic microcirculatory alterations described during inflammatory conditions are characterized by perfusion heterogeneity and theoretically pulmonary microcirculatory heterogene ity could lead to imbalance pulmonary ventilation/perfusion relationship. Thus, we hypothesized that systemic microvascular alterations could reflect increased VD/VT in ARDS.
Mucopolisacaridosis tipo VI (síndrome Maroteaux-Lamy) en la cultura precolombina de Colombia
(Universidad del Valle, 2014-04-01) Rodriguez, Carlos Armando
Mucopolysaccharidosis type VI or Maroteaux Lamy syndrome is an autosomal recessive lysosomal storage disorder resulting from a deficiency of arylsulfatase B, the clinical features include short stature, hepatosplenomegaly, dysostosis multiplex, stiff joints, corneal clouding, cardiac abnormalities, and facial dysmorphism, with intelligence usually normal. We present evidence of the possible existence of Maroteaux Lamy syndrome in pre-Columbian pottery 2000 years ago, in the Colombo-Ecuadorian Pacific coast of the Tumaco-Tolita culture.

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