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Ítem Implementación de un programa de farmacovigilancia en pacientes con artritis reumatoide en tratamiento con terapia biotecnológica en un centro de atención primaria en salud en el segundo semestre de 2016(Universidad Icesi, 2016-01-01) Crespo Luna, Jorge Hernán; Parody Rua, Elizabeth; Asesor Tesis; Asesor TesisLa artritis reumatoide es una enfermedad autoinmune que afecta mayoritariamente a más mujeres que hombres, tiene una etiología multifactorial pero no se conoce exactamente porque ocurre. Se caracteriza por causar dolor e inflamación en las articulaciones, que desencadenan la destrucción articular y ósea. Por lo cual es una enfermedad que causa incapacidad física y deterioro psicológico al que la padece. Con el desarrollo de los medicamentos biotecnológicos y el auge de la comercialización ellos en nuestro país para el tratamiento de la artritis reumatoide se debe ejercer un control estricto de los pacientes a los cuales está llegando esta medicación, por lo tanto, el desarrollo y ejecución de un programa de farmacovigilancia debe estar a primera mano cuando se debe monitorear la seguridad de los medicamentos.Ítem Implementación de un programa de seguimiento farmacoterapéutico en pacientes con artritis reumatoide en tratamiento con terapia biotecnológica en el segundo semestre de 2016(Universidad Icesi, 2016-01-01) López Burbano, Esteban; De Ávila Cantillo, Eduardo Enrique; Asesor Tesis; Asesor TesisLa artritis reumatoide es una enfermedad caracterizada por la aparición de signos de inflamación y dolor articular frecuente, los cuales aumentan con el pasar del tiempo. Esta es una enfermedad caracterizada por ser de origen autoinmune, crónica y de progresión lenta, la cual afecta tanto jóvenes como adultos sin distinguir edad, raza ni condición socioeconómica. Este proyecto se realizó con la finalidad de implementar un programa de seguimiento farmacoterapéutico en una población de pacientes con artritis reumatoide pertenecientes a un centro de atención primaria en salud de la ciudad de Cali (Promosalud I.P.S.) que están actualmente en tratamiento con medicamentos biotecnológicos, evaluando la farmacoterapia de los pacientes para identificar problemas relacionados con los medicacamentos.Ítem Modelo computacional del bloqueo del canal de potasio Kv13 por mutantes de las toxinas meutxka1 y meutxka3(Universidad Icesi, 2016-01-01) Duque Valderrutén, Katherin; Arango Mambuscay, Carlos Alberto; Asesor TesisLos canales de potasio dependientes de voltaje son sumamente importantes para la vida, ya que se encuentran en células excitables como las neuronales y en células musculares (O’Connor & Adams, 2010). En especial se ha demostrado que el canal de potasio Kv1.3 se encuentra implicado en la señalización, función y proliferación de células T (Wulff et al., 2003). Debido a lo anterior, el canal Kv1.3 es asociado a patologías mediadas por células T, como esclerosis múltiple, diabetes mellitus y artritis reumatoide. Por ello, un bloqueador selectivo de este canal podría impedir la propagación de las células T y sería un potente inmunosupresor.Ítem A rare association of localized scleroderma type morphea, vitiligo, autoimmune hypothyroidism, pneumonitis, autoimmune thrombocytopenic purpura and central nervous system vasculitis. Case report.(BioMed Central, 2012-12-20) Muñoz Buitrón, EvelynThe localized scleroderma (LS) known as morphea, presents a variety of clinical manifestations that can include systemic involvement. Current classification schemes divide morphea into categories based solely on cutaneous morphology, without reference to systemic disease or autoimmune phenomena. This classification is likely incomplete. Autoimmune phenomena such as vitiligo and Hashimoto thyroiditis associated with LS have been reported in some cases suggesting an autoimmune basis. To our knowledge this is the first case of a morphea forming part of a multiple autoimmune syndrome (MAS) and presenting simultaneously with autoimmune thrombocytopenic purpura and central nervous system vasculitis. CASE PRESENTATION: We report an uncommon case of a white 53 year old female patient with LS as part of a multiple autoimmune syndrome associated with pneumonitis, autoimmune thrombocytopenic purpura and central nervous system vasculitis presenting a favorable response with thrombopoietin receptor agonists, pulses of methylprednisolone and cyclophosphamide. CONCLUSION: Is likely that LS have an autoimmune origin and in this case becomes part of MAS, which consist on the presence of three or more well-defined autoimmune diseases in a single patient.Ítem Calcium, channels, intracellular signaling and autoimmunity(2014-01-01) Cañas Dávila, Carlos AlbertoCalcium (Ca2+) is an important cation able to function as a second messenger in different cells of the immune system, particularly in B and T lymphocytes, macrophages, and mastocytes, among others. Recent discoveries related to the entry of Ca2+ through the store-operated calcium entry (SOCE) have opened a new investigation area about the cell destiny regulated by Ca2+ especially in B and T lymphocytes. SOCE acts through calcium-release-activated calcium (CRAC) channels. The function of CRAC depends upon two recently discovered regulators: the Ca2+ sensor in the endoplasmic reticulum or stromal interaction molecule (STIM-1) and one subunit of CRAC channels called Orai1. This review focuses on the role of Ca2+ signals in B and T lymphocytes functions, the signaling pathways leading to Ca2+ influx, and the relationship between Ca2+ signals and autoimmune diseases.
Ítem B lymphocytes: development, tolerance, and their role in autoimmunity-focus on systemic lupus erythematosus.(Elsevier, 2013-01-01) Cañas Dávila, Carlos AlbertoB lymphocytes are the effectors of humoral immunity, providing defense against pathogens through different functions including antibody production. B cells constitute approximately 15% of peripheral blood leukocytes and arise from hemopoietic stem cells in the bone marrow. It is here that their antigen receptors (surface immunoglobulin) are assembled. In the context of autoimmune diseases defined by B and/or T cell autoreactive that upon activation lead to chronic tissue inflammation and often irreversible structural and functional damage, B lymphocytes play an essential role by not only producing autoantibodies but also functioning as antigen-presenting cells (APC) and as a source of cytokines. In this paper, we describe B lymphocyte functions in autoimmunity and autoimmune diseases with a special focus on their abnormalities in systemic lupus erythematosus.Ítem ¿Son las enfermedades autoinmunes predecibles?(Elsevier Science BV, 2012-02-01) Cañas Dávila, Carlos AlbertoAutoimmune diseases are complex diseases resulting of the interaction between both genetics and environmental factors over time. Different phases in the development of autoimmune diseases are characterized by the detection of serum autoantibodies several months or years before the onset of clinical manifestations and subsequent diagnosis. In addition to serum antibodies, genetic susceptibility factors may predict the future development of the disease. Currently, prediction in type 1 diabetes is the most accurate, with the analysis of genetic susceptibility factors in first-degree relatives of patients and several autoantibody tests. In the future, multiple antibodies test, in combination with the analysis of genetics, epigenetics and immunological anomalies in fine models may allow the precise prediction in autoimmune diseases. Prevention measures might thus be introduced as an attempt to avoid or delay the disease.Ítem Autoinmunidad y autoinflamación(Asociación Colombiana de Medicina Interna, 2011-04-01) Cañas Dávila, Carlos AlbertoObjetivo: exponer los aspectos que tienen en común o aquellos que diferencien las condiciones autoinmunes y autoinflamatorias, con énfasis en los mecanismos relacionados con la inmunidad innata. Métodos: se realiza una revisión sistemática de la literatura médica expuesta en la base de datos Medline (en lo que respecta a trabajos originales y revisiones de tema de los autores de dichos trabajos), de aspectos de la inmunidad innata y su relación con las enfermedades autoinmunes y autoinflamatorias, utilizando términos “MESH” como “autoimmuny diseases, autoinflammatory diseases, periodic fever syndromes, Toll-like receptor, NOD-like receptor” y otros que fuesen necesarios para lograr el objetivo de la revisión. Se procede luego a la consecución de los artículos completos, a su lectura, complementación con artículos referenciados relevantes, y luego se procede al ordenamiento, clasificación y posterior redacción del textoÍtem Evaluation of genetic association between an ITGAM non-synonymous SNP (rs1143679) and multiple autoimmune diseases.(Elsevier, 2012-02-12) Prahalad, SampathMany autoimmune diseases (ADs) share similar underlying pathology and have a tendency to cluster within families, supporting the involvement of shared susceptibility genes. To date, most of the genetic variants associated with systemic lupus erythematosus (SLE) susceptibility also show association with others ADs. ITGAM and its associated 'predisposing' variant (rs1143679, Arg77His), predicted to alter the tertiary structures of the ligand-binding domain of ITGAM, may play a key role for SLE pathogenesis. The aim of this study is to examine whether the ITGAM variant is also associated with other ADs. We evaluated case-control association between rs1143679 and ADs (N=18,457) including primary Sjögren's syndrome, systemic sclerosis, multiple sclerosis, rheumatoid arthritis, juvenile idiopathic arthritis, celiac disease, and type-1 diabetes. We also performed meta-analyses using our data in addition to available published data. Although the risk allele 'A' is relatively more frequent among cases for each disease, it was not significantly associated with any other ADs tested in this study. However, the meta-analysis for systemic sclerosis was associated with rs1143679 (p(meta)=0.008). In summary, this study explored the role of ITGAM in general autoimmunity in seven non-lupus ADs, and only found association for systemic sclerosis when our results were combined with published results. Thus ITGAM may not be a general autoimmunity gene but this variant may be specifically associated with SLE and systemic sclerosis.Ítem Local cartilage trauma as a pathogenic factor in autoimmunity (one hypothesis based on patients with relapsing polychondritis triggered by cartilage trauma).(Elsevier, 2012-01-01) Bonilla Abadía, FabioIn the recent years, it has been of great interest to study the binding mechanism between the innate and adaptive immune responses as interrelated processes for the development of multiple autoimmune diseases. Infection has been a well-known trigger of autoimmunity and trauma has been related as well too. Cryptogenic antigens release, recognition of pathogenic structure, and metabolic changes generated by both stimuli begin an inflammatory process which in turn activates the immune system amplifying T and B cell responses. The development of relapsing polychondritis after trauma may have a direct association with these events and in turn probably trigger autoimmune phenomena.